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Oakland Gardens, NY
A 25-year-old male asked:

Can you still have neuropathy with a normal skin biopsy and a normal emg/ncv ? i have burning pain for two weeks ...any clue what to do.?

2 doctor answers8 doctors weighed in
Dr. Bahman Omrani
Pain Management 17 years experience
Distal polyneuropath: Skin biopsy is useful for detection of peripheral neuropathy predominantly affecting small unmyelinated nerve fibers. A few biopsies obtained from the right location may be needed. Depending on the clinical presentation, nerve and possibly muscle biopsy is needed. Mri (cns/spine), labs including blood & CSF serologic studies, consultation with neurology, internal med/rheumatology may shed light.
Dr. Donald McCarren
Neurology 36 years experience
Small fiber neuropat: Hy has a broad differential that includes diabetes, lupus, amyloidosis, heavy metal toxicity, nutritional deficiency, sarcoidosis, hypothyroidism, celiac disease, lyme's disease, sjogren's syndrome, vasculitis, hiv, and alcoholism. Make sure these have been addressed if reasonable. A thermoregulatory sweat test can detect small fiber involvement but the cause remains elusive in about 40%.

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Last updated Nov 27, 2017

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