A 49-year-old female asked:
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how to treat slight elevated mch and mcv while on pemetrexed (year three) for nsclc--all other levels are normal but my onc suggests having bone marro?

2 doctor answers
Dr. Louis Cooper
47 years experience Pediatrics
More info: If Pemetrexed is the Folic Acid antagonist, one of the side effects is macrocytic (larger) red blood cells. This used to be a way to see if patients were taking their meds without a specific Methotrexate level. I cannot comment on the bone marrow, as i need more info.
Answered on Jun 30, 2014
Dr. Ed Friedlander
43 years experience Pathology
Your call: Folate (folic acid) antagonists tend to raise the mcv. Pemetrexid's been reported in a series to do this. It's between you and your oncologist whether to look for some other cause or to tap your marrow for whatever reason. http://meetinglibrary.asco.org/content/101609-114.
Answered on Jul 14, 2013

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