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A 32-year-old female asked:

if positive for the hla b27 gene and 2cases of iritis, does this mean i have ankylosing spondylitis for sure? r these 2 factors enough for a diagnosis?

3 doctor answers12 doctors weighed in
Dr. Bruce Saran
Ophthalmology 33 years experience
No: Hla b27 increases the risk for uveitis. Ankylosing spondylitis is associated with this but the diagnosis is made by physical exam and positive spine and hip x-rays. I have lots of patients with uveitis and hla b27 without other disease.
Dr. Robert Janigian
Ophthalmology 33 years experience
HLA B27 Iritis : 50 -55% of patients who present with iritis will be positive for hla b27 but a much smaller percentage will have an associated disease like as, reiter's, psoriasis or crohn's disease. If you have had negative xrays of your spine and you have no back stiffness then the chance of developing as at age 38 is low but still possible.
Dr. Peter Ihle
Orthopedic Surgery 54 years experience
Yes: The most common presenting features r si joint inflammation & decreased chest expansion, along with iritis. The 1'st 2 r the earliest signs, the primary is decreased chest expansion.
Dr. Ari Weitzner
Ophthalmology 33 years experience
for diagnosis, you need the x-ray findings in the bones.
Sep 15, 2013

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