A 18-year-old female asked:
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how can a baby be born with down sydrome or any kind of sydrome? would it have to run in the family of mine of my spouses?

1 doctor answer
Dr. James Ferguson
45 years experience Pediatrics
Abnormal chromosomes: Ds occurs when either the egg or sperm are defective.Instead of containing 23 single chromosomes that join their pair at conception, the egg or sperm brings an extra #21.The baby ends up with 3 of the #21 or ds. It can occur at any age but is more common as the mother gets older. It does not "run in families".
Answered on May 1, 2013

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