A 39-year-old member asked:
I want to know what is the difference between von willebrand's disease and hemophilia?
1 doctor answer
Dr. Michael Engel answered
19 years experience in Pediatric Hematology and Oncology
Different but....: Related. Vwf is a glycoprotein important for primary hemostasis. It cross links collagen at a site of injury with gpib on platelets. Deficiency leads to failure of primary hemostasis (ie, bleeding). Vwf also protects fviii from degradation. Fviii partners with fix to activate fx to ultimately promote clotting. So, while different, fviii & vwf deficiency can have similar presentations. Simplified!
Answered on Aug 15, 2013
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