A 39-year-old member asked:
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I want to know what is the difference between von willebrand's disease and hemophilia?

1 doctor answer
Dr. Michael Engel
19 years experience in Pediatric Hematology and Oncology
Different but....: Related. Vwf is a glycoprotein important for primary hemostasis. It cross links collagen at a site of injury with gpib on platelets. Deficiency leads to failure of primary hemostasis (ie, bleeding). Vwf also protects fviii from degradation. Fviii partners with fix to activate fx to ultimately promote clotting. So, while different, fviii & vwf deficiency can have similar presentations. Simplified!
Answered on Aug 15, 2013
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2 comments
Dr. Louis Cooper
47 years experience in Pediatrics
von Willebrand disease can be clinically presenting as nose bleeds, excess menstrual bleeding in ladies. Often called vascular hemophilia---several types---classic hemophilia can be mild, moderate or severe and often presents in the newborn at circumcision with unexplained bleeding or in children with bleeding into a joint or oral bleeding after a fall or tongue trauma.
Aug 15, 2013
Dr. Michael Engel
19 years experience in Pediatric Hematology and Oncology
Provided original answer
Should also be clear that hemophilia A is factor VIII deficiency. These short spaces make it hard to give detailed answers.
Aug 15, 2013

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