A female asked:
Disclaimer

i am currently on bupropion xl and was prescribed tramadol 50 mg to take every 8 hrs for a few days for back pain. is this safe for a limited time?

2 doctor answers
Dr. Kathy Robinson
32 years experience Family Medicine
Not recommended: Since bupropion and tramadol both lower the seizure threshold, It is not recommended that you take them at the same time. The combination could cause a seizure.
Answered on Sep 2, 2018
Dr. Daniel Ziegler
30 years experience Emergency Medicine
Its risky: Unfortunately both medications are known to cause seizures and that risk is increased with the combination but at normal doses that risk is still relatively low. Tramadol was marketed as a non-opiate pain medication and this is inaccurate. It does act on opiate receptors to reduce pain and being a synthetic it has side effects that true opiates dont so it's worse than plain old opiate pain killers
Answered on Jan 5, 2019

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Related questions:

A 49-year-old female asked:
Dr. Eric Weisman
36 years experience Neurology
No not safe: Both lower seizure threshold considerably. Wellbutrin and Tramadol alone can precipitate seizures.
2
2 thanks
A female asked:
Dr. Bassam Amawi
49 years experience Psychiatry
Tramadol and wellbut: May have some risk if taken together, talk with u provider.
1
1 comment
1
1 thank
A male asked:
Dr. Dean Giannone
25 years experience Internal Medicine
No.: I don’t believe that the combination of Tramadol and Bupropion would be prudent.
A 42-year-old male asked:
Dr. Marsha Davis
28 years experience Internal Medicine
Yes: There are no drug interactions.
1
1 thank

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