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Laredo, TX
A 56-year-old female asked:

is it true that zoloft reduces the effect of fioricet? how many hours apart should i take them?

2 doctor answers6 doctors weighed in
Dr. Edward Kuhnley
Child Psychiatry 45 years experience
Zoloft has no known: interaction with fioricet alone. However Zoloft oral possibly decreases effects of Fioricet with Codeine oral by altering drug metabolism of the codeine. Conversion of codeine to it's active form is reduced, possibly reducing the effect of codeine. If problems occur discuss with prescriber. Best regards for health.
Dr. Linda Callaghan
Addiction Medicine 53 years experience
The use of: Zoloft and Fioricet can increase the side effects causing drowsiness, confusion, difficulty concentrating and in elderly people can cause poor motor coordination impaired thinking and judgement. If possible,do not use at the same time. If you have severe headache, take the Fioricet and take the Zoloft 24 hours later.

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Last updated Jul 12, 2018

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