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A 41-year-old male asked:

What is the signifigance of a mono clonal t cell beta gene rearrangement found in blood ? all other labs are normal. is this a sign of lymphoma ?

1 doctor answer3 doctors weighed in
Dr. Michael Benjamin
Hematology and Oncology 24 years experience
Probably not: Monoclonal populations of immune cells can be a challenge to diagnose. Conditions like RA can associate with t-cell monoclonal populations. If the counts are otherwise normal, the group of cells should be followed but probably do not represent malignancy per se, though technically are a "neoplastic" proliferation of cells. http://www.ncbi.nlm.nih.gov/pubmed/18474096 Check with your doctor.

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Last updated Nov 24, 2015

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