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Spokane, WA
A 29-year-old female asked:

two negative blood test for celiac disease is it possible to still have it and it be the cause of bone loss? how do i test and make sure 100%

2 doctor answers2 doctors weighed in
Dr. Ed Friedlander
Pathology 44 years experience
There's no 100%: The labs are probably not totally sensitive / specific but they're pretty good. Have you had a biopsy? This is one to work out with your physician. Bone loss won't be the primary manifestation of celiac disease despite "pop" wisdom. "Low blood pressure" isn't an illness. A full workup, including some zebras like porphyria or other neuropathies, may be a consideration along with supportive Dr.
Dr. James Ferguson
Pediatrics 46 years experience
What test ?: Some assume when they have blood drawn, they look at everything, which is false. You must have a test for specific antibodies ( tissue transaminases) that are present in celiac disease. Even then, the test may not be at a level that is diagnostic. If you have no evidence on appropriate testing, which also includes a tissue biopsy, you don't have CD. There are more common reasons for bone loss.

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Last updated May 1, 2017

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