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Brookfield, WI
A 27-year-old male asked:

Can hydroxyurea cause polycythemia vera to mutate into leukemia?

1 doctor answer2 doctors weighed in
Dr. Marek Bozdech
Hematology and Oncology 49 years experience
Controversial: There is a risk of transformation to acute leukemia just from having P Vera. But it is very low. Whether hydroxyurea increases that risk has not be definitively answered. Most hematologists find the benefit of controlling the disease greatly outweighs the risk. There is a new drug - Jakafi (ruxolitinib) - just approved for PV if not well controlled or if side effects of HU too great. Talk to your hematologist.

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Last updated Mar 26, 2020
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