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A 37-year-old female asked about a 61-year-old female:

Why do warfarin levels change so much when nothing different is done?

2 doctor answers5 doctors weighed in
Dr. Steven Ajluni
Cardiology 35 years experience
Multiple interaction: Warfarin inhibits vit k action in the liver (a necessary step in forming many of your clotting factors). It is ingested in your diet and stored in the liver. Genetic variations in how the vit k is incorporated enzymatically into these factors is relevant (sometimes people require either very little or lots of warfarin). Diet changes w more or less vit k affect pt inr as do drug interactions.
Dr. Calvin Weisberger
Cardiology 51 years experience
Warfarin: Complex interaction of intrinsic and extrinsic factors, always some reason.

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Last updated Sep 28, 2016

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