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A 34-year-old member asked:

What type of genetic disorder is alzheimer's disease?

3 doctor answers5 doctors weighed in
Dr. Ladislav Volicer
Geriatric Psychiatry 62 years experience
Rare: In rare families, there is an abnormal gene that is transmitted to children and there is 50% probability that the children will eventually develop alzheimer's disease. However, it is usually in families where several members develop alzheimer's disease in early age.
Dr. Bennett Machanic
Neurology 52 years experience
Some contribution: There are several rare genetic issues which cause younger symptoms, and these include mutations in ps-1, ps-2, and app genetics. The main potential risk factor involves apolipoprotein epsilon-4 alleles, and the homozygous pattern is the highest risk, and the epsilon-2 pattern relatively protective.
Dr. Rawan Tarawneh
A Verified Doctoranswered
A US doctor answeredLearn more
Not always genetic: Most cases of alzheimer's (85-90%) are not genetic, although the risk is increased if there is a family history. It is only genetic in 10-15% of the cases, in which case it is autosomal dominant; if a parent is affected, there is a 50% chance that a child will be normal and 50% chance that the child will carry the mutation and have the disease. These include mutations in app, ps-1, and ps-2.

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Similar questions

A 42-year-old member asked:

Can you tell me is alzheimer's disease genetic?

1 doctor answer2 doctors weighed in
Dr. Bennett Machanic
Neurology 52 years experience
Two categories: Several families with genetic Alzheimer's issues are noted, most commonly mutations involving pre-senilin i and ii, amyloid precursor protein, and less frequent patterns. Vast majority of cases are sporadic associated with aging, and the peak onset occurs by age 85. In these situations, the genetic patterns are not clearly explanations.
A 49-year-old member asked:

Is alzheimer's disease genetic?

2 doctor answers4 doctors weighed in
Dr. Ladislav Volicer
Geriatric Psychiatry 62 years experience
It depends: In rare families, there is an abnormal gene that is transmitted to children and there is 50% probability that the children will eventually develop alzheimer's disease. However, it is usually in families where several members develop alzheimer's disease in early age. Otherwise, there is inheritance of the form of apolipoprotein that increases the risk of developing alzheimer's disease earlier.

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Last updated Jun 18, 2015

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