A 18-year-old male asked:
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i had a chronic overdose on aspirin, and took about 500 tablets each 350 mg, what's the chance of my liver being damaged?

2 doctor answers
Dr. Otto Placik
34 years experience Plastic Surgery
Get evaluated: This is a serious condition and i would highly recommend that you get all your labs evaluated including liver function studies as well as possible diagnostic imaging.
Answered on Jan 29, 2013
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Dr. Dan Fisher
27 years experience Internal Medicine
Not sure.: Not sure how you took this, but toxic effects of Aspirin are noted at time of acute overdose not at some point later. Peak levels occur within a few hours and half life is a few hours unless very large quantities are taken when half lives may be measured up to thirty hours. It would seem that if you are fine now you have not overwhelmed your liver and your function should remain normal.
Answered on May 19, 2017
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Related questions:

A 18-year-old male asked:
Dr. Geoffrey Rutledge
41 years experience Internal Medicine
Not at all: Aspirin (asa or acetylsalicylic acid) is not toxic to the liver (but Acetaminophen or tylenol (acetaminophen) is if taken in large doses). Asa overdo ... Read More
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A 34-year-old male asked:
Dr. Dan Fisher
27 years experience Internal Medicine
Not sure.: All of the NSAID's carry approximately the same toxicity when given at equivalent dose. The major concern is renal and not liver toxicity.
A 24-year-old male asked:
Dr. Tracy Lovell
21 years experience Rheumatology
See below: A lot depends on whether you have cirrhosis from the fatty liver disease, but one baby Aspirin may be okay. Check your with your doctor to confirm.
A 40-year-old member asked:
Dr. Geoffrey Rutledge
41 years experience Internal Medicine
No : Aspirin is not toxic to the liver the way alcohol is. By contrast, the active ingredient in tylenol (acetaminophen) is highly toxic to the liver in la ... Read More
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