A 52-year-old member asked:
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my son is 14yrs short stature (xray bone age 16) endrocrinologist suggested femara (letrozole) to stop bone plates from closing entirely. is this treatment safe?

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Dr. Vered Lewy-Weiss
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Unknown : Aromatase inhibitors to keep growth plates open at bone age of 16 isn't worth potential risks considering growth plates nearly fused. Vertebral bone defects and questionable effects on fertility are only two of many questions not answered yet. No long term safety data exist. At this time aromatase inhibition to ⬆ ht is considered experimental by the pediatric endocrine society.
Answered on Dec 10, 2013
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