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A 41-year-old member asked:

What are the affects of nitroprusside used in conjunction with dobutamine?

3 doctor answers4 doctors weighed in
Dr. Mark Rasak
Cardiology 33 years experience
Depends on dosing: Dobutamine is an agent that helps the weak heart pump better by stimulating beta receptors in the heart. At lower doses it doesnt affect the blood vessels but higher doses it can also lower the tone of the ateries and makes it easier for the heart to pump. This tone is aka systemic vascular resistence. By lowering the svr the cariac out put will increase. Nipride (nitroprusside) has no beta stim effects only svr.
Dr. Budi Bahureksa
Cardiology 31 years experience
CHF: In the presence of chf, it lowers the blood pressure in the heart itself -- allowing the heart to function easier.
Dr. Bennett Werner
Cardiology 44 years experience
Vasodilitation: Nitroprusside very potently dilates blood vessels and reduces the workload of the heart. Dobutamine stimulates cardiac contraction but also constricts blood vessels in a dose dependent fashion which can counteract the nitroprusside effect. The combination has been used to treat cardiogenic shock.

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Last updated May 6, 2018

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