A 52-year-old member asked:
what happens genetically that causes chronic myelogenous leukemia?
2 doctor answers
Dr. Stephen Noga answered
33 years experience Medical Oncology
Translocation: A big word but dna is always recombining when cells divide. In this case, a piece of dna from chromosome 9 moves over to chromosome 22 which essentially turns on a switch that produces an enzyme that promotes uncontrolled cell division and leukemia. Modern drugs are targeted to prevent the action of this enzyme.
Answered on Aug 3, 2017
Dr. Agos Luca answered
Specializes in Pathology
See below: CML is a type of leukemia caused by a genetic abnormalty, namely a translocation between chromosomes 9 and 22 resulting in the philadelphia chromosome. This leads to a fusion of two genes, bcr ; abl, and the fusion product stimulates the proliferation of myeloid cells uncontrolably. However, the exact cause of the translocation itself is uncertain.
Answered on Jun 10, 2014
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