A 52-year-old member asked:
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what happens genetically that causes chronic myelogenous leukemia?

2 doctor answers
Dr. Stephen Noga
33 years experience Medical Oncology
Translocation: A big word but dna is always recombining when cells divide. In this case, a piece of dna from chromosome 9 moves over to chromosome 22 which essentially turns on a switch that produces an enzyme that promotes uncontrolled cell division and leukemia. Modern drugs are targeted to prevent the action of this enzyme.
Answered on Aug 3, 2017
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Dr. Sahba Ferdowsi
17 years experience General Practice
Good answer. Wishing you'all the very best.
Feb 16, 2012
Dr. Agos Luca
Dr. Agos Luca answered
Specializes in Pathology
See below: CML is a type of leukemia caused by a genetic abnormalty, namely a translocation between chromosomes 9 and 22 resulting in the philadelphia chromosome. This leads to a fusion of two genes, bcr ; abl, and the fusion product stimulates the proliferation of myeloid cells uncontrolably. However, the exact cause of the translocation itself is uncertain.
Answered on Jun 10, 2014

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