A 37-year-old female asked:
Disclaimer

my neurologist ask me to do the ana test , because i'm probably a ms patient first time it was positive and after 2 years with the ifa , negative. why?

2 doctor answers
Dr. Gurmukh Singh
48 years experience Pathology
Biologic variation: Titers of antibodies do decline with time, if there is no ongoing stimulation. You probably had a low titer ANA and it declined becasue there was no more stimulation to the system. Please note that this is similar to the titer of antibodyies to vaccines declining with age.
Answered on May 12, 2015
2
2 thanks
Dr. Bennett Machanic
51 years experience Neurology
See below: Typical to check ANA to rule out lupus as cause of brain symptoms, and a low titer is of limited significance, and does indeed fluctuate.
Answered on Sep 6, 2014

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Get help now:

Ask doctors free
Personalized answers
Free
Talk to a doctor
Unlimited visits
$10/month

Related questions:

A 34-year-old female asked:
Dr. Bennett Machanic
51 years experience Neurology
Consider these: The paroxysmal episodes could be associated with epilepsy or migraine, and this needs to be considered. An eeg could be useful. Also, consider an un ... Read More
1
1 thank
A member asked:
Dr. John Chiu
Dr. John Chiu answered
56 years experience Allergy and Immunology
See rheumatologist?: This suggests that you may have an autoimmune disorder which however cannot be diagnosed by this test alone. This also has nothing to do with MS even ... Read More
A 55-year-old female asked:
Dr. Gurmukh Singh
48 years experience Pathology
You may: You may see an internist for your general health evaluation, however, the internist may still refer you to a neurologist. Wish you good health!
1
1 thank
A 45-year-old female asked:
Dr. Donald Colantino
60 years experience Internal Medicine
ANA: Your ANA is nondiagnostic. I recommend consulting a dermatologist who can determine whether your hair loss is temporary or permanent and can order app ... Read More

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Get help now:

Ask doctors free
Personalized answers
Free
Talk to a doctor
Unlimited visits
$10/month