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Richmond Hill, GA
A 40-year-old male asked:

I was diagnosed with pls. i do have muscle atrophy in both legs. whats the diff between upper motor neuron dominant als and pls?

1 doctor answer3 doctors weighed in
Dr. Geoffrey Rutledge
Internal Medicine 41 years experience
PLS versus ALS: Primary lateral sclerosis (pls) is a rare cause of spasticity without muscle atrophy ( no loss of spinal motor neurons). Extensive atrophy should not occur with pls, but reduced activity by itself can cause some atrophy. Als involves both upper motor neurons (causing spasticity) and lower motor neurons, causing atrophy. Pls has little effect on life span, hereditary spastic paraparesis can mimic.

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Last updated Dec 9, 2013

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