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Charlottesville, VA
A 43-year-old female asked:

i have a low iga and lupus like symptoms. my ana is negative. can i develop lupus?

2 doctor answers4 doctors weighed in
Dr. Douglas Mund
Rheumatology 46 years experience
Unlikely: Lupus like symptoms is quite vague. As lupus potentially can affect any organ system in the body, many symptoms are consistent with those seen in lupus. Low IgA is not a typical feature of lupus. It is more commonly seen in certain bowel disorders in which, many symptoms overlap with those seen in lupus.
Dr. Ed Friedlander
Pathology 44 years experience
Probably not: There are a host of poorly-understood diseases in the "common variable immunodeficiency" category, including those that may include an arthritis and feelings of being unwell. In lupus, the labs, including the ana, usually are positive well before the disease announces itself, as we've learned from looking at preserved specimens. Good luck.

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Similar questions

A 32-year-old member asked:

Is it possible for a person to be diagnosed with lupus if they are ANA negative?

1 doctor answer2 doctors weighed in
Dr. Ed Friedlander
Pathology 44 years experience
Rare: Ana's are sometimes done wrong even by good, big labs. If you are speaking of systemic lupus and the person has the classic clinical picture, then i would question the reliability of the lab's ANA and try a different lab or proceed as if lupus was indeed present.
CA
A 29-year-old female asked:

Could i still have lupus even though my ANA is negative?

2 doctor answers3 doctors weighed in
Dr. Larry Greenbaum
Rheumatology 37 years experience
Unlikely: Rarely patients with a negative ANA are diagnosed with lupus. Many of those patients have other abnormal labs, especially for sjogren's syndrome. Speak to a rheumatologist.
A 40-year-old member asked:

Would a person be diagnosed with lupus if they are ANA negative?

2 doctor answers3 doctors weighed in
Dr. Ronald Krauser
Rheumatology 52 years experience
Rarely: It is an unusual situation but there are individuals with lupus and negative blood tests.
FL
A 33-year-old female asked:

My DSDNA is 101, my RF is 26.6 and my ANA is negative. What kind of direction diagnosis wise can I expect?

1 doctor answer2 doctors weighed in
Dr. John Chiu
Dr. John Chiu answered
Allergy and Immunology 57 years experience
Symptoms?: One cannot diagnose a disease based on lab tests alone. Yet the tests suggests that you are prone to have an autoimmune disease. Suggest you consult a rheumatologist if you have symptoms. Having said that it is unusual to have a positive DsDNA and negative ANA. The workup will be guided by your symptoms and physical findings.

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Last updated Jul 7, 2019

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