A 53-year-old member asked:
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Could hemophilia occur due to a mutation?

1 doctor answer
Dr. Robert Kwok
32 years experience in Pediatrics
Yes, a gene mutation: Hemophilia "A" is a hereditary bleeding disorder where there is a deficiency in clotting factor VIII (factor VIII is needed for blood clotting). It is inherited on the X-chromosome (sex-linked). Men only have 1 "X", so if their "X" is mutated, they will have the disease. Women have 2 "X's", so they can have 1 mutated "X" and 1 normal "X", and be a carrier of the disease, with mild or no symptoms.
Answered on Mar 21, 2018

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Related questions:

A member asked:
Dr. Donald Nino
37 years experience in Family Medicine
Hemophilia: A mutation on the x chromosome that affects the blood clotting factors viii or ix.
A 49-year-old member asked:
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Yes: Both hemophilia a and b are due to mutations in genes on the x chromosome.
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