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What makes some hemoglobinopathies unstable?

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Dr. Valentin Drezaliu
Obstetrics and Gynecology 20 years experience
Hemoglobinopathies: When the structure of hemoglobin is altered due to mutation then it is more prone to earlier destruction by different mechanism. As a result the red blood cells will age and destroy much quicker than a red cell with normal hemoglobin which as a lifespan of 120 days.It is diagnosted in early age in infant due to anemia related complications, and hemoglobin byproducts metabolism.Hope it helps.
Dr. Peter Kurzweil
Internal Medicine 50 years experience
Trait vs disease.: Hemoglobinopathies are a variety of inherited diseases where the hemoglobin molecule (part of RBC that attaches to o2 which all cells need to live) is malformed. Examples are sickle cell & thalassemia anemia. Abnormal gene from one parent, usually have 'trait' and live healthy life. Gene from each parent, get the disease: infection, stress, a cold, other events can set off a crisis and instability.

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Last updated Jan 15, 2015

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