A 39-year-old member asked:
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can alpha thalassemia be dominant?

2 doctor answers
Dr. Robert Kwok
33 years experience Pediatrics
Not quite: People normally have 4 Alpha globulin genes. A mutation in 1, 2, 3, or all 4 genes leads to the 4 levels of Alpha thalassemia. The genetics of the disorder is not all-or-none, not dominant-recessive. Instead, the more mutations, the worse the disease. One mutation = silent carrier (no symptoms), 2 muta. = Alpha trait (mild symptoms), 3 muta. = HGB h (moderate symptoms), 4 muta. = bart's (deaths).
Answered on Jun 24, 2014
Dr. Bachar Al-Alami
36 years experience ADHD and Autism
YES : Homozygous Alpha (0) thalassemia, in which no Alpha globin chains can be produced, is incompatible with extrauterine life, leading to hydrops fetalis and/or death shortly after delivery.
Answered on Jun 24, 2014

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