A 29-year-old member asked:
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what happens to the insulin receptors to make them insulin resistant?

2 doctor answers
Dr. Richard Shewbridge
33 years experience Endocrinology
Great question!: If you figure that one out, you will probably win the nobel prize in medicine. There are easily over 100 different defects in Insulin signaling (how Insulin talks to cells) which have been described in type 2 diabetic patients, ranging from mild to severe. That's one of the reasons why coming up with a cure for this disease is so difficult.
Answered on Mar 12, 2016
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3 thanks
Dr. Gutti Rao
Dr. Gutti Rao answered
46 years experience Hospital-based practice
Insulin receptors: In type 2 diabetes mellitus, there is a down regulation ( less number) of Insulin receptors otherwise called adiponectin receptors. Increasing Insulin administration may not help as Insulin has to attach itself to these receptors on the cell membrane. Medication class called tzd up regulates these receptors helping circulating Insulin to attach to the cells for its action.
Answered on Jun 25, 2014

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A 30-year-old member asked:
Dr. Robert Lang
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Lets sugar into cell: The Insulin receptor opens a channel to allow glucose into the cells for energy to maintain their function.
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Dr. David Sneid
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Complex interaction: Phosphoprotein phosphatase is activated by the insulin, which indicates that there is a high concentration of glucose in the blood. The enzyme then ac ... Read More
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Dr. Bennett Machanic
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Yes: glucose and oxygen are both critical to brain function.
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Dr. Luis Villaplana
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Obesity: Excess Insulin production is related to obesity, and viceversa. Vicious cycle. They keep each other going.

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