A 29-year-old member asked:
what happens to the insulin receptors to make them insulin resistant?
2 doctor answers
Dr. Richard Shewbridge answered
33 years experience Endocrinology
Great question!: If you figure that one out, you will probably win the nobel prize in medicine. There are easily over 100 different defects in Insulin signaling (how Insulin talks to cells) which have been described in type 2 diabetic patients, ranging from mild to severe. That's one of the reasons why coming up with a cure for this disease is so difficult.
Answered on Mar 12, 2016
Dr. Gutti Rao answered
46 years experience Hospital-based practice
Insulin receptors: In type 2 diabetes mellitus, there is a down regulation ( less number) of Insulin receptors otherwise called adiponectin receptors. Increasing Insulin administration may not help as Insulin has to attach itself to these receptors on the cell membrane. Medication class called tzd up regulates these receptors helping circulating Insulin to attach to the cells for its action.
Answered on Jun 25, 2014
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