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A 35-year-old member asked:

What are the differences between buprenorphine, methadone?

2 doctor answers6 doctors weighed in
Dr. Stuart Wasser
Addiction Medicine 35 years experience
C below: Bup is a partial agonist which means it has a ceiling effect and alsi it can not be combined with other opioids. It will last longer in the body. Methadone is a full agonist with no ceiling effect and it can be used with other opioids and lead to overdose. Meth has more endocrine effects, cardiac effects, respiratory effects. There are also more laws restricting meth's use.
Dr. Alex Wargo
Family Medicine 43 years experience
Many, many, many: Not to say one is better than another, they both have their pros and cons. They are structurally different. The way they bind to receptors in the brain is unique to each drug, and they are also schedule by the dea differently. Methadone is a cii (schedule 2) & Buprenorphine is a ciii(schedule 3). A cii can not be refilled and in a clinic, Methadone is under tight control.

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