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A 28-year-old male asked:

doez prazosin cross the bbb and work in the cns? ive read conflicting things on pubmed and elsewhere. does any alpha-1 blocker cross the bbb?

1 doctor answer3 doctors weighed in
Dr. Dariush Saghafi
Neurology 33 years experience
You must be reading: about its use as it treats nightmares in the brain. So yes, it clearly crosses the BBB and clearly WORKS. I treat many people with PTSD and nightmares from war vets to civilians, rape victims, assault, other abuse victims who have terrible nightmares and it practically clears everything up inside of 1 week or 2. Problems are lowered blood pressure, allergic reactions, and, first dose syncope.

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Last updated May 17, 2015

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