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A 37-year-old member asked:

is ivf ever done without fertility drugs?

2 doctor answers9 doctors weighed in
Dr. Gerard Honore
Fertility Medicine 29 years experience
Yes: It is, but much less often. History's first ivf pregnancy was in an unstimulated cycle! there are also a variety of 'minimal stimulation' protocols that involve fertility drugs, but shorter or lower dose regimens.
Dr. Khurram Rehman
Fertility Medicine 26 years experience
Yes but ...: Yes, but despite early success natural cycle ivf (no fertility drugs) or 'minimal stimulation ivf' with Clomid (clomiphene) or low-dose fertility shots has much lower chances of success compared with 'conventional ivf' with higher doses of injectable medications. Costs are lower, the risk of multiple pregnancy is lower, but results are worse.
Dr. Khurram Rehman
Fertility Medicine 26 years experience
Provided original answer
It's unlikely but possible for an egg to fertilize naturally during an IVF cycle - we are mostly removing eggs from the follicles in your ovaries at the time of egg retrieval, but a small number of eggs could remain in or around the ovaries. Depending on your age, and egg quality, putting back a single embryo may be approriate if you want to avoid twins.
May 30, 2012

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Last updated Nov 28, 2017
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