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A 24-year-old female asked:

Why are 2 umbilical cords sometimes used in an allogeneic stem cell transplant?

2 doctor answers2 doctors weighed in
Dr. Stephen Southard
Internal Medicine 15 years experience
Remember: Double cord blood transplantations are completed because the number of stem cells in one unit of cord blood is usually not enough to repopulate the bone marrow of adult sized persons. So two helps make sure that the transplant is successful. Hope that helps.
Dr. Matthew Fero
Medical Oncology 31 years experience
Increased stem cells: The rate of engraftment in adults following an umbilical cord blood stem cell transplant (UCBT) is quite slow. This increases risk of infection while the WBC count is low, and requires a longer period of RBC and platelet transfusion support. To speed up the rate of engraftment double UCBT are often used. Early both cord units might produce WBC, but later a single unit predominates.

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Last updated Jan 4, 2015
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