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A 37-year-old member asked:

Could a doc please explain what the genetic basis of sickle cell anaemia is?

1 doctor answer1 doctor weighed in
Dr. James Ferguson
Pediatrics 46 years experience
Mutations: True sickle cell disease requires a recessive gene contribution from both parents. These parents are asymptomatic carriers and may not know they have the gene.At conception the sperm carries one s gene that joins with the mothers s gene, so the pair both have the ss information as will every cell in the body.The baby with this ss pair will have ss disease.

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A 49-year-old member asked:

Could you describe what the genetic basis of sickle cell anaemia is?

1 doctor answer1 doctor weighed in
Dr. James Ferguson
Pediatrics 46 years experience
No: True sickle cell disease requires a recessive gene contribution from both parents. These parents are asymptomatic carriers and may not know they have the gene.At conception the sperm carries one s gene that joins with the mothers s gene, so the pair both have the ss information as will every cell in the body.

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Last updated Jun 3, 2014
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