A 45-year-old member asked:
hodgkins lymphoma graft-versus-host disease, what is this?
2 doctor answers
Dr. Eric Chevlen answered
47 years experience Medical Oncology
Transplant vs pt.: Hodgkin's disease may be treated with a transplantation of stem cells from another person. High dose chemotherapy is given to eradicate the cancer, but it also eradicates the patient's normal marrow. The transplantation replaces the patient's marrow. But because the transplanted cells recognize the patient's cells as foreign, they try to eliminate patient (host) cells. Thus,graft vs host disease.
Answered on Dec 31, 2014
1
1 comment
Dr. Matthew Fero commented
31 years experience Medical Oncology
One of the therapeutic benefits of an allogeneic transplant is that the transplanted immune system also attacks the tumor cells. This is often referred to as graft vs. tumor or graft vs. lymphoma.
Dec 31, 2014
Dr. Matthew Fero answered
31 years experience Medical Oncology
Cellular immunity: Graft vs. host disease (GVHD) occurs when T lymphocytes from a donor cause inflammation in the normal tissues of a patient. This is a common side effect of allogeneic bone marrow transplants because billions of T cells are infused along with the bone marrow stem cells. It can also occur as a rare, unintended consequence of blood transfusion in Hodgkins patients.
Answered on Jan 21, 2015
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