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A 46-year-old member asked:

Why is fulvestrant not used with pre-menopausal patient?

1 doctor answer2 doctors weighed in
Dr. Bryan Treacy
Gynecology 35 years experience
Competition: Circulating Estradiol competes with for the estrogen receptor in premenopausal women. Estradiol surges during ovulation to fairly high levels where in postmenopause, Estradiol is made from converting androgens/adrenal hormones (like dhea) in peripheral fat. Levels are not as high so competition for the receptor is less.

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A 35-year-old member asked:

Why is fulvestrant not used for pre-menopausal patients?

1 doctor answer2 doctors weighed in
Dr. Sewa Legha
Medical Oncology 50 years experience
High estrogens: Premenopausal women produce large quantities of estrogens which feed the Cancer. So the treatments that work best for them are those that remove the source of estrogens or block its effects on the tumor. Fulvestant does not work that way, so it is relatively less effective in premenopausal patients.

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Last updated Dec 23, 2014

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