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A 40-year-old member asked:

what are the chances for a man with marfan syndrome to pass it on to his children?

1 doctor answer6 doctors weighed in
Dr. Scott McLean
Clinical Genetics 35 years experience
50% for each child: Marfan syndrome is caused by a mutation of the fbn1 gene on chromosome 15. An affected man (or woman) has one normal and one mutant fbn1 gene in each of his (or her) cells. For each of his children, the chance that he will pass on the mutation is 1/2 or 50%. This pattern of inheritance is called autosomal dominant.

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Last updated May 27, 2016

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