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A 34-year-old member asked:

Which is more potent sinemet (carbidopa and levodopa) or the generic of carbidopa/levodopa?

1 doctor answer3 doctors weighed in
Dr. Michael Lin
Internal Medicine 9 years experience
Neither: Generic drugs are held to standards where the manufacturer must prove "bioequivalence" to the branded drug. The molecules must be structurally the same, and the same standard of quality and purity must be met. The pills and the packaging themselves may look different, but the active ingredient is the same. It can be thought of as the difference between clorox bleach and safeway brand bleach.
Dr. Eric Farbman
Neurology 26 years experience
I agree with the above. The exception is likely Sinemet CR. The generic form of this medicine is often very ineffective. The immediate release Sinemet and its generic formulation seem to be virtually identical in effect.
Apr 5, 2013

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Last updated Apr 5, 2013
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