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A 49-year-old male asked:

Why is luvox (fluvoxamine) usually considered the last choice for depression when an ssri is prescribed...

3 doctor answers3 doctors weighed in
Dr. Donald Jacobson
A Verified Doctoranswered
A US doctor answeredLearn more
Several reasons: Introduced to the us for ocd only at first, with a small sales force. Cost was then a big factor. Drug-drug interactions make it a drug that cannot be prescribed without some considerable thought. It is probably the last ssri most american psychiatrists would think to use.
Dr. Christine Norton
Family Medicine 24 years experience
New choices: Luvox (fluvoxamine) is one of the older ssri type antidepressants and therefore tends to have more problems with side effects than the newer ones. It also has a serious side of increased suicidal thoughts and risks of attempted suicide which has been included in an fda black box warning. As a result, it is not a first choice ssri. There are safer, effective drugs that can be used first.
Dr. Heidi Fowler
Psychiatry 25 years experience
Luvox: Agree with Dr. Jacobson. It only has an FDA indication for Obsessive Compulsive Disorder. It has to be used off-label for treatment of depression. I always used it for OCD only because it was expensive and not first line for depression.

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Last updated Jan 9, 2019
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