A panel of human cell-based artificial APC enables the expansion of long-lived antigen-specific CD4+ T cells restricted by prevalent HLA-DR alleles.
Int. Immunol., Nov;22(11):863-73 (2010)
Expansion of allospecific regulatory T cells after anergized, mismatched bone marrow transplantation.
Sci Transl Med., Oct;1(1):1ra3 (2009)
Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21.
Clin. Cancer Res., Oct;14(19):6125-36 (2008)
Induction of alloanergy in human donor T cells without loss of pathogen or tumor immunity.
Transplantation., Sep;86(6):854-64 (2008)
CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans.
Clin. Cancer Res., Sep;14(17):5626-34 (2008)
Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies.
Blood., Sep;112(6):2232-41 (2008)
Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells.
J. Immunol., Aug;181(3):1859-68 (2008)
Long-term survival after autologous bone marrow transplantation for follicular lymphoma in first remission.
Biol. Blood Marrow Transplant., Sep;13(9):1057-65 (2007)
Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation.
Br. J. Haematol., Nov;127(3):322-5 (2004)
Common gamma chain-signaling cytokines promote proliferation of T-cell acute lymphoblastic leukemia.
Haematologica., Dec;89(12):1459-67 (2004)
Presence of anti-kinectin and anti-PMS1 antibodies in Japanese aplastic anaemia patients.
Br. J. Haematol., Jan;128(2):221-3 (2005)
Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed acute lymphoblastic leukemia.
Exp. Hematol., Mar;33(3):286-94 (2005)
Increasing incidence of late second malignancies after conditioning with cyclophosphamide and total-body irradiation and autologous bone marrow transplantation for non-Hodgkin's lymphoma.
J. Clin. Oncol., Apr;23(10):2208-14 (2005)
Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia.
Blood., Sep;106(5):1749-54 (2005)
Unexpected association between induction of immunity to the universal tumor antigen CYP1B1 and response to next therapy.
Clin. Cancer Res., Jun;11(12):4430-6 (2005)
Phase I/II combined chemoimmunotherapy with carcinoembryonic antigen-derived HLA-A2-restricted CAP-1 peptide and irinotecan, 5-fluorouracil, and leucovorin in patients with primary metastatic colorectal cancer.
Clin. Cancer Res., Aug;11(16):5993-6001 (2005)
Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaB.
Blood., Jan;107(1):285-92 (2006)
Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity.
Blood., Feb;107(4):1528-36 (2006)
Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia.
Cancer Res., Nov;65(21):10050-8 (2005)
Leukemia-stimulated bone marrow endothelium promotes leukemia cell survival.
Exp. Hematol., May;34(5):610-21 (2006)
Efficient presentation of naturally processed HLA class I peptides by artificial antigen-presenting cells for the generation of effective antitumor responses.
Clin. Cancer Res., May;12(10):2967-75 (2006)
Identification of an immunogenic CD8+ T-cell epitope derived from gamma-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia.
Blood., Oct;108(8):2662-8 (2006)
Long-lived antitumor CD8+ lymphocytes for adoptive therapy generated using an artificial antigen-presenting cell.
Clin. Cancer Res., Mar;13(6):1857-67 (2007)
cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression.
Blood., Feb;101(3):998-1006 (2003)
MUC1-like tandem repeat proteins are broadly immunogenic in cancer patients.
Cancer Immun., Mar;3:3 (2003)
Differential localization and function of ADP-ribosylation factor-6 in anergic human T cells: a potential marker for their identification.
J. Immunol., Aug;171(4):1691-6 (2003)
Autoantibodies frequently detected in patients with aplastic anemia.
Blood., Dec;102(13):4567-75 (2003)
IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.
Blood., Mar;103(5):1891-900 (2004)
Autologous bone marrow transplantation for marginal zone non-Hodgkin's lymphoma.
Leuk. Lymphoma., Feb;45(2):315-20 (2004)
pH-triggered microparticles for peptide vaccination.
J. Immunol., Aug;173(4):2578-85 (2004)
Chemoattractants MDC and TARC are secreted by malignant B-cell precursors following CD40 ligation and support the migration of leukemia-specific T cells.
Blood., Aug;98(3):533-40 (2001)
The impact of external beam radiation therapy prior to autologous bone marrow transplantation in patients with non-Hodgkin's lymphoma.
Biol. Blood Marrow Transplant., 7(8):446-53 (2001)
Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells.
Nat. Immunol., Dec;2(12):1174-82 (2001)
Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses.
Blood., Feb;99(4):1465-73 (2002)
CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells.
J. Immunol., Mar;168(6):2729-36 (2002)
Adoptive T-cell therapy for B-cell acute lymphoblastic leukemia: preclinical studies.
Blood., Nov;94(10):3531-40 (1999)
p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes.
Nat. Med., Mar;6(3):290-7 (2000)
Expression of MHC class II-associated invariant chain (Ii;CD74) in thymic epithelial neoplasms.
Appl. Immunohistochem. Mol. Morphol., Sep;8(3):210-5 (2000)
Bone marrow transplantation for low-grade lymphoma and chronic lymphocytic leukemia.
Semin. Hematol., Apr;36(2):209-16 (1999)
Transplantation of anergic histoincompatible bone marrow allografts.
N. Engl. J. Med., Jun;340(22):1704-14 (1999)
A Phase II study of adjuvant therapy with anti-B4-blocked ricin after autologous bone marrow transplantation for patients with relapsed B-cell non-Hodgkin's lymphoma.
Clin. Cancer Res., Sep;5(9):2392-8 (1999)
Long-term follow-up of autologous bone marrow transplantation in patients with relapsed follicular lymphoma.
Blood., Nov;94(10):3325-33 (1999)
High dose therapy and autologous stem cell transplantation in follicular non-Hodgkin's lymphoma.
Leuk. Lymphoma., Jan;28(3-4):219-30 (1998)
Predictive value of clonality assays in patients with non-Hodgkin's lymphoma undergoing autologous bone marrow transplant: a single institution study.
Blood., Jun;91(12):4496-503 (1998)
The leukocyte semaphorin CD100 is expressed in most T-cell, but few B-cell, non-Hodgkin's lymphomas.
Am. J. Pathol., Jul;153(1):255-62 (1998)
The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor.
J. Immunol., Sep;161(6):2708-15 (1998)
Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes.
J. Immunol., Sep;161(6):2780-90 (1998)
Phase II clinical trial of bolus infusion anti-B4 blocked ricin immunoconjugate in patients with relapsed B-cell non-Hodgkin's lymphoma.
Clin. Cancer Res., Nov;4(11):2599-604 (1998)
Human non-germinal center B cell interleukin (IL)-12 production is primarily regulated by T cell signals CD40 ligand, interferon gamma, and IL-10: role of B cells in the maintenance of T cell responses.
J. Exp. Med., Jan;189(1):1-12 (1999)
T cell mediated immunotherapy for B cell lymphoma.
J. Mol. Med., Mar;77(3):322-31 (1999)
B7-mediated costimulation and the immune response.
Blood Rev., Jun;10(2):111-27 (1996)
Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation.
Proc. Natl. Acad. Sci. U.S.A., Oct;93(21):11780-5 (1996)
Autologous tumor infiltrating T cells cytotoxic for follicular lymphoma cells can be expanded in vitro.
Blood., May;89(10):3806-16 (1997)
Ex vivo generation of human anti-pre-B leukemia-specific autologous cytolytic T cells.
Blood., Jul;90(2):549-61 (1997)
Prediction of therapy-related acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) after autologous bone marrow transplant (ABMT) for lymphoma.
Am. J. Hematol., Sep;56(1):45-51 (1997)
Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1.
Science., Oct;278(5335):124-8 (1997)
Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death.
J. Immunol., Oct;159(7):3156-67 (1997)
CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy.
J. Clin. Invest., Dec;100(11):2757-65 (1997)
Monitoring minimal residual disease.
Semin. Oncol., Oct;20(5 Suppl 5):143-55 (1993)
CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy.
J. Exp. Med., Nov;180(5):1665-73 (1994)
Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5.
J. Immunol., Dec;153(11):5038-48 (1994)
Differential expression of alternate mB7-2 transcripts.
J. Immunol., Dec;155(12):5490-7 (1995)
B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.
Immunity., May;2(5):523-32 (1995)
IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells.
J. Immunol., Feb;188(4):1609-19 (2012)
Establishment of antitumor memory in humans using in vitro-educated CD8+ T cells.
Sci Transl Med., Apr;3(80):80ra34 (2011)
Identification of a new HLA-A*0201-restricted cryptic epitope from CYP1B1.
Int. J. Cancer., Jun;115(2):333-6 (2005)
Rare naturally occurring immune responses to three epitopes from the widely expressed tumour antigens hTERT and CYP1B1 in multiple myeloma patients.
Clin. Exp. Immunol., Sep;141(3):558-62 (2005)
Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia.
Blood., Dec;106(13):4389-96 (2005)
Rapid, reliable and inexpensive quality assessment of biotinylated cRNA.
Braz. J. Med. Biol. Res., May;39(5):589-93 (2006)
Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application.
Blood., May;99(9):3319-25 (2002)
From genomics to cancer vaccines: patient-tailored or universal vaccines?
Curr. Opin. Mol. Ther., Dec;4(6):572-6 (2002)
Viral antigen-specific CD8+ T-cell responses are impaired in multiple myeloma.
Br. J. Haematol., Jun;121(6):842-8 (2003)
Loss of marrow reserve from dose-intensified chemotherapy results in impaired hematopoietic reconstitution after autologous transplantation: CD34(+), CD34(+)38(-), and week-6 CAFC assays predict poor engraftment.
Exp. Hematol., Dec;28(12):1325-33 (2000)
Human macrophage-derived chemokine (MDC) is strongly expressed following activation of both normal and malignant precursor and mature B cells.
Curr. Top. Microbiol. Immunol., 246:103-10 (1999)
In vivo expression of B7-1 and B7-2 by follicular lymphoma cells can prevent induction of T-cell anergy but is insufficient to induce significant T-cell proliferation.
Blood., Dec;90(11):4297-306 (1997)
Co-Author, " Increasing incidence of late second malignancies after conditioning with cyclophosphamide and total-body irradiation and autologous bone marrow transplantation for non-Hodgkin's lymphoma."
Journal of Clinical Oncology
Co-Author, "Identification of a new HLA-A*0201-restricted cryptic epitope from CYP1B1."
International Journal of Cancer
Co-Author, "Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia."
Co-Author, "Phase I/II combined chemoimmunotherapy with carcinoembryonic antigen-derived HLA-A2-restricted CAP-1 peptide and irinotecan, 5-fluorouracil, and leucovorin in patients with primary metastatic colorectal cancer."
Clinical Cancer Research
Co-Author, " Unexpected association between induction of immunity to the universal tumor antigen CYP1B1 and response to next therapy."
Clinical Cancer Research
Co-Author, "Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia."
Co-Author, " Antigen-specific T cell memory is preserved in children treated for acute lymphoblastic leukemia."