Type I interferon: a new player in TNF signaling.
Curr. Dir. Autoimmun., 11:94-104 (2010)
Systemic lupus erythematosus monocytes are less responsive to interleukin-10 in the presence of immune complexes.
Arthritis Rheum., Jan;63(1):212-8 (2011)
Suppression of TNF-Î± and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27.
J. Immunol., Dec;185(11):7047-56 (2010)
IFN-Î³ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling.
Proc. Natl. Acad. Sci. U.S.A., Nov;107(45):19438-43 (2010)
TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages.
Proc. Natl. Acad. Sci. U.S.A., Jan;108(4):1573-8 (2011)
Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway.
Immunology., Apr;132(4):567-77 (2011)
How ITAMs inhibit signaling.
Sci Signal., 4(169):pe20 (2011)
Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors.
Arthritis Res. Ther., 13(4):234 (2011)
Inflammatory signaling in macrophages: transitions from acute to tolerant and alternative activation states.
Eur. J. Immunol., Sep;41(9):2477-81 (2011)
TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.
J. Exp. Med., Feb;209(2):319-34 (2012)
ITAM-coupled receptors inhibit IFNAR signaling and alter macrophage responses to TLR4 and Listeria monocytogenes.
J. Immunol., Apr;188(7):3447-57 (2012)
The IFN signature and STAT1 expression in RA synovial fluid macrophages are induced by TNFÎ± and counter-regulated by synovial fluid microenvironment.
Regulation of inflammatory responses in tumor necrosis factor - activated and rheumatoid arthritis synovial macrophages by Janus kinase inhibitors.
Arthritis Rheum., Aug (2012)
IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression.
J. Immunol., Aug;183(4):2444-55 (2009)
Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors.
J. Immunol., Dec;183(11):7223-33 (2009)
Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases.
Immunity., Oct;31(4):539-50 (2009)
Expression profiling reveals alternative macrophage activation and impaired osteogenesis in periprosthetic osteolysis.
J. Orthop. Res., Jan;26(1):106-16 (2008)
Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages.
Proc. Natl. Acad. Sci. U.S.A., Feb;107(7):3012-7 (2010)
Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins.
Immunity., Apr;32(4):518-30 (2010)
Overview of the biology of type I interferons.
Arthritis Res. Ther., 12 Suppl 1:S1 (2010)
Calcium-activated pathways and oxidative burst mediate zymosan-induced signaling and IL-10 production in human macrophages.
J. Immunol., May;184(10):5545-52 (2010)
The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate.
J. Immunol., Jul;185(2):1265-73 (2010)
The type I interferon signaling pathway is a target for glucocorticoid inhibition.
Mol. Cell. Biol., Oct;30(19):4564-74 (2010)
STAT activation during viral infection in vivo: where's the interferon?
Cell Host Microbe., Aug;8(2):132-5 (2010)
Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1.
J. Immunol., Nov;185(9):5023-31 (2010)
IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.
Immunity., May;24(5):563-74 (2006)
Glucocorticoid modulation of cytokine signaling.
Tissue Antigens., Jul;68(1):1-12 (2006)
Twist mediates suppression of inflammation by type I IFNs and Axl.
J. Exp. Med., Aug;203(8):1891-901 (2006)
Involvement of complement receptor 3 (CR3) and scavenger receptor in macrophage responses to wear debris.
J. Orthop. Res., Nov;24(11):2036-44 (2006)
Dysregulation of interleukin-10-dependent gene expression in rheumatoid arthritis synovial macrophages.
Arthritis Rheum., Sep;54(9):2711-21 (2006)
FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin.
Immunity., Jan;26(1):67-78 (2007)
Suppression of the effector phase of inflammatory arthritis by double-stranded RNA is mediated by type I IFNs.
J. Immunol., Feb;178(4):2204-11 (2007)
Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages.
Hum. Immunol., Mar;68(3):156-64 (2007)
A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells.
J. Biol. Chem., Jun;282(26):18676-85 (2007)
Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation.
J. Leukoc. Biol., Aug;82(2):237-43 (2007)
'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages.
Nat. Immunol., Feb;9(2):186-93 (2008)
Insoluble immune complexes are most effective at triggering IL-10 production in human monocytes and synergize with TLR ligands and C5a.
Clin. Immunol., Apr;127(1):56-65 (2008)
TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes.
Nat. Immunol., Apr;9(4):378-87 (2008)
IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38.
J. Immunol., May;180(9):6325-33 (2008)
IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways.
J. Immunol., Jun;180(12):8057-65 (2008)
A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways.
Nat. Rev. Immunol., Oct;8(10):816-22 (2008)
Lipopolysaccharide-induced expression of matrix metalloproteinases in human monocytes is suppressed by IFN-gamma via superinduction of ATF-3 and suppression of AP-1.
J. Immunol., Oct;181(7):5089-97 (2008)
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways.
Immunity., Nov;29(5):691-703 (2008)
Targeting cytokines in inflammatory diseases: focus on interleukin-1-mediated autoinflammation.
F1000 Biol Rep., 1:70 (2009)
Type I interferon modulation of cellular responses to cytokines and infectious pathogens: potential role in SLE pathogenesis.
Autoimmunity., Dec;36(8):473-9 (2003)
IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis.
J. Immunol., May;172(10):6476-81 (2004)
Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors.
Nat. Immunol., Nov;5(11):1181-9 (2004)
Homeostatic role of interferons conferred by inhibition of IL-1-mediated inflammation and tissue destruction.
J. Immunol., Jul;175(1):131-8 (2005)
Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway.
Proc. Natl. Acad. Sci. U.S.A., Jul;102(29):10267-72 (2005)
IFN-gamma-primed macrophages exhibit increased CCR2-dependent migration and altered IFN-gamma responses mediated by Stat1.
J. Immunol., Sep;175(6):3637-47 (2005)
Regulation of macrophage phenotype by long-term exposure to IL-10.
Immunobiology., 210(2-4):77-86 (2005)
Kinetics of IL-10-induced gene expression in human macrophages.
Immunobiology., 210(2-4):87-95 (2005)
The conserved Leu-724 residue is required for both serine phosphorylation and co-activator recruitment for Stat1-mediated transcription activation in response to interferon-gamma.
J. Biol. Chem., Dec;280(51):41844-51 (2005)
Wear debris inhibition of anti-osteoclastogenic signaling by interleukin-6 and interferon-gamma. Mechanistic insights and implications for periprosthetic osteolysis.
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Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation.
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Selective regulation of IL-10 signaling and function by zymosan.
J. Immunol., Apr;176(8):4785-92 (2006)
Costimulation of chemokine receptor signaling by matrix metalloproteinase-9 mediates enhanced migration of IFN-alpha dendritic cells.
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Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.
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Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases.
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IL-4 selectively inhibits IL-2-triggered Stat5 activation, but not proliferation, in human T cells.
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Inhibition of interleukin 2 signaling and signal transducer and activator of transcription (STAT)5 activation during T cell receptor-mediated feedback inhibition of T cell expansion.
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Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids.
Proc. Natl. Acad. Sci. U.S.A., Aug;97(17):9573-8 (2000)
Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways.
J. Immunol., Nov;165(9):5227-37 (2000)
Jak-STAT signaling pathways in cells of the immune system.
Rev Immunogenet., 2(2):220-30 (2000)
Cross-talk between IL-1 and IL-6 signaling pathways in rheumatoid arthritis synovial fibroblasts.
J. Immunol., Nov;167(9):5395-403 (2001)
Inhibition of IL-6 signaling by a p38-dependent pathway occurs in the absence of new protein synthesis.
J. Leukoc. Biol., Jul;72(1):154-62 (2002)
Sensitization of IFN-gamma Jak-STAT signaling during macrophage activation.
Nat. Immunol., Sep;3(9):859-66 (2002)
Rheumatoid arthritis synoviocyte survival is dependent on Stat3.
J. Immunol., Dec;169(11):6610-6 (2002)
Can SOCS make arthritis better?
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Inhibition of IFN-gamma signaling by glucocorticoids.
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Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis.
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Reprogramming of IL-10 activity and signaling by IFN-gamma.
J. Immunol., Nov;171(10):5034-41 (2003)
Activation of monocyte effector genes and STAT family transcription factors by inflammatory synovial fluid is independent of interferon gamma.
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Cytokines and STATs: how can signals achieve specificity?
Immunity., Jul;3(1):1-4 (1995)
Cytokine expression and cell activation in inflammatory arthritis.
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Circulating human B cells that express surrogate light chains and edited receptors.
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Negative regulation of osteoclast precursor differentiation by CD11b and Î²2 integrin-BCL6 signaling.
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Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling.
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Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms.
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