Antimicrobial peptides: old molecules with new ideas.
J. Invest. Dermatol., Mar;132(3 Pt 2):887-95 (2012)
Microbial symbiosis with the innate immune defense system of the skin.
J. Invest. Dermatol., Oct;131(10):1974-80 (2011)
Protecting the boundary: the sentinel role of host defense peptides in the skin.
Cell. Mol. Life Sci., Jul;68(13):2189-99 (2011)
Cyclooxygenase-2 enhances antimicrobial peptide expression and killing of Staphylococcus aureus.
J. Immunol., Dec;185(11):6535-44 (2010)
Staphylococcus aureus hijacks a skin commensal to intensify its virulence: immunization targeting Î²-hemolysin and CAMP factor.
J. Invest. Dermatol., Feb;131(2):401-9 (2011)
Passive immunoprotection targeting a secreted CAMP factor of Propionibacterium acnes as a novel immunotherapeutic for acne vulgaris.
Vaccine., Apr;29(17):3230-8 (2011)
Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression.
J. Invest. Dermatol., Apr;130(4):985-94 (2010)
Vaccination targeting surface FomA of Fusobacterium nucleatum against bacterial co-aggregation: Implication for treatment of periodontal infection and halitosis.
Vaccine., Apr;28(19):3496-505 (2010)
The essentiality of alpha-2-macroglobulin in human salivary innate immunity against new H1N1 swine origin influenza A virus.
Proteomics., Jun;10(12):2396-401 (2010)
Neuroendocrine nicotinic receptor activation increases susceptibility to bacterial infections by suppressing antimicrobial peptide production.
Cell Host Microbe., Apr;7(4):277-89 (2010)
Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections.
J. Invest. Dermatol., Sep;130(9):2211-21 (2010)
Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS.
Mol. Immunol., Dec;47(2-3):449-56 (2009)
The molecular pathology of rosacea.
J. Dermatol. Sci., Aug;55(2):77-81 (2009)
AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense.
Trends Immunol., Mar;30(3):131-41 (2009)
NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury.
J. Biol. Chem., May;284(19):12762-71 (2009)
Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes.
J. Invest. Dermatol., Sep;129(9):2148-55 (2009)
A novel vaccine targeting Fusobacterium nucleatum against abscesses and halitosis.
Vaccine., Mar;27(10):1589-95 (2009)
Cathelicidin antimicrobial peptides inhibit hyaluronan-induced cytokine release and modulate chronic allergic dermatitis.
J. Immunol., Sep;181(6):3915-22 (2008)
FGF-10 and specific structural elements of dermatan sulfate size and sulfation promote maximal keratinocyte migration and cellular proliferation.
Wound Repair Regen., 17(1):118-26 (2009)
Toll-like receptors in skin infections and inflammatory diseases.
Infect Disord Drug Targets., Sep;8(3):144-55 (2008)
Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes.
J. Invest. Dermatol., Nov;128(11):2646-54 (2008)
Antibodies elicited by inactivated propionibacterium acnes-based vaccines exert protective immunity and attenuate the IL-8 production in human sebocytes: relevance to therapy for acne vulgaris.
J. Invest. Dermatol., Oct;128(10):2451-7 (2008)
Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin.
J. Immunol., Jun;180(11):7565-73 (2008)
Entamoeba histolytica induces intestinal cathelicidins but is resistant to cathelicidin-mediated killing.
Infect. Immun., Jan;80(1):143-9 (2012)
PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection.
Sci Transl Med., May;4(135):135ra66 (2012)
Statins enhance formation of phagocyte extracellular traps.
Cell Host Microbe., Nov;8(5):445-54 (2010)
Streptococcal inhibitor of complement promotes innate immune resistance phenotypes of invasive M1T1 group A Streptococcus.
J Innate Immun., 2(6):587-95 (2010)
Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8.
Proc. Natl. Acad. Sci. U.S.A., Dec;107(51):22249-54 (2010)
Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid.
J. Invest. Dermatol., May;130(5):1297-306 (2010)
The host defense peptide cathelicidin is required for NK cell-mediated suppression of tumor growth.
J. Immunol., Jan;184(1):369-78 (2010)
M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment.
J. Mol. Med., Apr;88(4):371-81 (2010)
Innate barriers against infection and associated disorders.
Drug Discov Today Dis Mech., Jun;5(2):145-152 (2008)
Differing effects of exogenous or endogenous cathelicidin on macrophage toll-like receptor signaling.
Immunol. Cell Biol., 87(6):496-500 (2009)
ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis.
J Innate Immun., 1(5):494-506 (2009)
Antimicrobial peptides, skin infections, and atopic dermatitis.
Semin Cutan Med Surg., Jun;27(2):144-50 (2008)
Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivo.
Proteomics., Aug;8(16):3406-15 (2008)
Skin microbiota: a source of disease or defence?
Br. J. Dermatol., Mar;158(3):442-55 (2008)
A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes.
Antimicrob. Agents Chemother., May;52(5):1834-6 (2008)
Induction and exacerbation of psoriasis with Interferon-alpha therapy for hepatitis C: A review and analysis of 36 cases.
History of eczema herpeticum is associated with the inability to induce human Î²-defensin (HBD)-2, HBD-3 and cathelicidin in the skin of patients with atopic dermatitis.
Br. J. Dermatol., Sep;163(3):659-61 (2010)