Bcl-2 differentially regulates Ca2+ signals according to the strength of T cell receptor activation.
J. Cell Biol., Jan;172(1):127-37 (2006)
Live free or die: an immature T cell decision encoded in distinct Bcl-2 sensitive and insensitive Ca2+ signals.
Cell Cycle., Jun;5(11):1171-4 (2006)
Bcl-2-regulated calcium signals as common mediators of both apoptosis and autophagy.
Dev. Cell., Feb;12(2):178-9 (2007)
Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis.
Annu. Rev. Physiol., 70:73-91 (2008)
Dexamethasone-induced inositol 1,4,5-trisphosphate receptor elevation in murine lymphoma cells is not required for dexamethasone-mediated calcium elevation and apoptosis.
J. Biol. Chem., Apr;283(16):10357-65 (2008)
Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid-treated lymphocytes.
Autophagy., Jul;4(5):612-20 (2008)
Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals.
Mol. Cell., Jul;31(2):255-65 (2008)
Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor.
Biochim. Biophys. Acta., Jun;1793(6):971-8 (2009)
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor.
Proc. Natl. Acad. Sci. U.S.A., Aug;106(34):14397-402 (2009)
Glucocorticoid-mediated inhibition of Lck modulates the pattern of T cell receptor-induced calcium signals by down-regulating inositol 1,4,5-trisphosphate receptors.
J. Biol. Chem., Nov;284(46):31860-71 (2009)
Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia.
Cell Death Differ., Sep;17(9):1381-91 (2010)
The glucocorticoid-induced gene tdag8 encodes a pro-apoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis.
J. Biol. Chem., Dec;279(51):52850-9 (2004)
Apoptosis and autophagy: decoding calcium signals that mediate life or death.
Cold Spring Harb Perspect Biol., Oct;2(10):a005579 (2010)
Glucocorticoid-mediated repression of the oncogenic microRNA cluster miR-17~92 contributes to the induction of Bim and initiation of apoptosis.
Mol. Endocrinol., Mar;25(3):409-20 (2011)
Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca(2+) signaling and disease.
Cell Calcium., Sep;50(3):234-41 (2011)
Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes.
J. Biol. Chem., Aug;286(34):30181-9 (2011)
Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals.
J. Biol. Chem., Jul;278(29):27053-8 (2003)
Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis.
J. Biol. Chem., Jun;278(26):23861-7 (2003)
Ins(1,4,5)P3-mediated calcium signals and apoptosis: is there a role for Bcl-2?
Biochem. Soc. Trans., Oct;31(Pt 5):958-9 (2003)
Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance.
J. Cell. Sci., Nov;116(Pt 22):4493-9 (2003)