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Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-Î².
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The lysophosphatidic acid receptor LPA1 promotes epithelial cell apoptosis after lung injury.
Am. J. Respir. Cell Mol. Biol., Mar;46(3):355-64 (2012)
Role of the lysophospholipid mediators lysophosphatidic Acid and sphingosine 1-phosphate in lung fibrosis.
Proc Am Thorac Soc., Jul;9(3):102-10 (2012)
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Rapid Evolution of HIV-1 to Functional CD8+ T Cell Responses in Humanized BLT Mice.
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HIV-infected T cells are migratory vehicles for viral dissemination.
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Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10.
Am. J. Respir. Cell Mol. Biol., Oct;31(4):395-404 (2004)
Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment.
Nat. Immunol., Oct;4(10):982-90 (2003)
T-cell trafficking in asthma: lipid mediators grease the way.
Nat. Rev. Immunol., Sep;4(9):711-24 (2004)
BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation.
J. Exp. Med., Jul;202(1):97-110 (2005)
Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.
Circulation., Jul;112(4):578-86 (2005)
Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1.
Am. J. Physiol. Lung Cell Mol. Physiol., Jan;290(1):L170-8 (2006)
The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans.
Blood., Jan;107(2):444-53 (2006)
A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis.
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J. Immunol., Apr;176(8):4959-67 (2006)
Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.
Circulation., May;113(19):2301-12 (2006)
Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction.
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Inhibited aortic aneurysm formation in BLT1-deficient mice.
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The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.
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