Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.
J. Biol. Chem., Jul;269(26):17741-8 (1994)
PDZ domains: structural modules for protein complex assembly.
J. Biol. Chem., Feb;277(8):5699-702 (2002)
Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development.
Dev. Cell., Apr;12(4):587-602 (2007)
Clinical trials for neuroprotection in Parkinson's disease: overcoming angst and futility?
Curr. Opin. Neurol., Aug;20(4):477-83 (2007)
Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1.
J. Neurosci., Feb;28(7):1697-708 (2008)
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.
Nature., Jun;357(6378):500-3 (1992)
Amyloid beta-peptide is produced by cultured cells during normal metabolism.
Nature., Sep;359(6393):322-5 (1992)
beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.
J. Biol. Chem., Feb;268(5):3021-4 (1993)
Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules.
Ann. N. Y. Acad. Sci., Sep;695:109-16 (1993)
Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.
J. Biol. Chem., Nov;268(31):22959-62 (1993)
Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein.
EMBO J., Feb;13(3):534-42 (1994)
Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.
Proc. Natl. Acad. Sci. U.S.A., Oct;89(20):9439-43 (1992)
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
Nature., Dec;360(6405):672-4 (1992)
Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion.
J. Neurosci., Dec;11(12):3783-93 (1991)