(R)-thionisoxetine, a potent and selective inhibitor of central and peripheral norepinephrine uptake.
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Antagonism of serotonin3 (5-HT3) receptors within the blood-brain barrier prevents cisplatin-induced emesis in dogs.
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Comparison of indolidan analog binding sites of drug antibody and sarcoplasmic reticulum with inhibition of cyclic AMP phosphodiesterase.
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Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.
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mCPP but not TFMPP is an antagonist at cardiac 5HT3 receptors.
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Chiral recognition of pinacidil and its 3-pyridyl isomer by canine cardiac and smooth muscle: antagonism by sulfonylureas.
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Synthesis of a tritium-labeled indolidan analogue and its use as a radioligand for phosphodiesterase-inhibitor cardiotonic binding sites.
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Analysis of the binding sites for the cardiotonic phosphodiesterase inhibitor [3H]LY186126 in ventricular myocardium.
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Depletion of cardiac norepinephrine but not brain catecholamines by MPTP-N-oxide in mice.
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Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.
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Characterization and pharmacological relevance of high affinity binding sites for [3H]LY186126, a cardiotonic phosphodiesterase inhibitor, in canine cardiac membranes.
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Comparative effects of 1-ethyl- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridines on catecholamine concentrations in mouse brain and heart.
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Electrophysiologic and antiarrhythmic activities of 4-amino-N-[2-(diethylamino)ethyl]-3,5-dimethylbenzamide, a sterically hindered procainamide analogue.
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Comparison of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) effects on mouse heart norepinephrine.
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Specific binding of [3H]LY186126, an analogue of indolidan (LY195115), to cardiac membranes enriched in sarcoplasmic reticulum vesicles.
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Electrophysiological effects of flecainide enantiomers in canine Purkinje fibres.
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Molecular basis for the in vitro and in vivo cardiotonic activities of AR-L100.
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LY195115: a potent, selective inhibitor of cyclic nucleotide phosphodiesterase located in the sarcoplasmic reticulum.
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Pharmacology of LY195115, a potent, orally active cardiotonic with a long duration of action.
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Molecular structure of the dihydropyridazinone cardiotonic 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-pyridazinyl)- 2H-indol-2-one, a potent inhibitor of cyclic AMP phosphodiesterase.
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Bipyridine cardiotonics: the three-dimensional structures of amrinone and milrinone.
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Roles for Ca++ and cyclic AMP in mediating the cardiotonic actions of isomazole (LY175326).
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Pharmacology of LY175326: a potent cardiotonic agent with vasodilator activities.
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