Partners healthcare system
Brigham and womens hospital
Massachusetts eye and ear infirmary
New england baptist hospital
New england rehabilitation hospital
Shaughnessy kaplan rehabilitation hospital
Massachusetts General Hospital
HIV and HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen species and NFkappaB.
J. Biol. Chem., Jan;286(4):2665-74 (2011)
HIV infection increases HCV-induced hepatocyte apoptosis.
J. Hepatol., Apr;54(4):612-20 (2011)
IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway.
J. Hepatol., Aug;55(2):289-98 (2011)
Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase.
J. Infect. Dis., Aug;204(4):609-16 (2011)
Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus.
J. Am. Chem. Soc., Apr;134(16):6896-9 (2012)
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Nat. Chem. Biol., Mar;5(3):154-6 (2009)
A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.
Cell Host Microbe., Mar;5(3):298-307 (2009)
Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.
Bioorg. Med. Chem. Lett., Nov;19(22):6319-25 (2009)
Small-molecule modulators of the Sonic Hedgehog signaling pathway.
Mol Biosyst., Jan;6(1):44-54 (2010)
Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent manner.
Gastroenterology., Jun;138(7):2509-18, 2518.e1 (2010)
Suppressor of cytokine signaling 3 suppresses hepatitis C virus replication in an mTOR-dependent manner.
J. Virol., Jun;84(12):6060-9 (2010)
A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication.
Gastroenterology., Jan;132(1):311-20 (2007)
Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen.
Antimicrob. Agents Chemother., Oct;51(10):3756-9 (2007)