ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.
Am. J. Respir. Crit. Care Med., May;183(10):1344-53 (2011)
The three R's of lung health and disease: repair, remodeling, and regeneration.
J. Clin. Invest., Jun;121(6):2065-73 (2011)
Multiple ways to die: delineation of the unfolded protein response and apoptosis induced by Surfactant Protein C BRICHOS mutants.
Int. J. Biochem. Cell Biol., Jan;44(1):101-12 (2012)
Selective inhibition of inducible NO synthase activity in vivo reverses inflammatory abnormalities in surfactant protein D-deficient mice.
J. Immunol., Dec;179(12):8090-7 (2007)
Surfactant protein D protects against acute hyperoxic lung injury.
Am. J. Respir. Crit. Care Med., Oct;178(8):805-13 (2008)
Immune reconstitution during Pneumocystis lung infection: disruption of surfactant component expression and function by S-nitrosylation.
J. Immunol., Feb;182(4):2277-87 (2009)
Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases.
J. Biol. Chem., Jun;284(24):16667-78 (2009)
Delayed clearance of pneumocystis carinii infection, increased inflammation, and altered nitric oxide metabolism in lungs of surfactant protein-D knockout mice.
J. Infect. Dis., Apr;189(8):1528-39 (2004)
Processing of surfactant protein C requires a type II transmembrane topology directed by juxtamembrane positively charged residues.
J. Biol. Chem., Nov;278(48):47979-86 (2003)
IL-4 induces production of the lung collectin surfactant protein-D.
J. Allergy Clin. Immunol., Mar;113(3):439-44 (2004)
Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species.
Infect. Immun., Oct;72(10):6002-11 (2004)
Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene.
Pediatr. Res., Jan;57(1):89-98 (2005)
Surfactant protein C biosynthesis and its emerging role in conformational lung disease.
Annu. Rev. Physiol., 67:663-96 (2005)
A surfactant protein C precursor protein BRICHOS domain mutation causes endoplasmic reticulum stress, proteasome dysfunction, and caspase 3 activation.
Am. J. Respir. Cell Mol. Biol., Jun;32(6):521-30 (2005)
Alveolar surfactant protein D content modulates bleomycin-induced lung injury.
Am. J. Respir. Crit. Care Med., Oct;172(7):869-77 (2005)
Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression.
Am. J. Physiol. Lung Cell Mol. Physiol., Aug;291(2):L191-9 (2006)
IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response.
J. Immunol., Mar;176(6):3557-65 (2006)
Surfactant protein C: its unique properties and emerging immunomodulatory role in the lung.
Microbes Infect., Jul;8(8):2317-23 (2006)
SP-D-deficient mice are resistant to hyperoxia.
Am. J. Physiol. Lung Cell Mol. Physiol., Apr;292(4):L861-71 (2007)
GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo.
Development., Jan;134(1):189-98 (2007)