Abiraterone inhibits 3Î²-hydroxysteroid dehydrogenase: a rationale for increasing drug exposure in castration-resistant prostate cancer.
Clin. Cancer Res., Jul;18(13):3571-9 (2012)
Minor Activities and Transition State Properties of the Human Steroid Hydroxylases Cytochromes P450c17 and P450c21, from Reactions Observed with Deuterium-Labeled Substrates.
Biochemistry., Aug (2012)
Spironolactone prevents chlorthalidone-induced sympathetic activation and insulin resistance in hypertensive patients.
Hypertension., Aug;60(2):319-25 (2012)
The life and scientific contributions of Keith L. Parker, 1953-2008.
Mol. Cell. Endocrinol., Apr;336(1-2):191-2 (2011)
Clinical, biochemical, and molecular characterization of macronodular adrenocortical hyperplasia of the zona reticularis: a new syndrome.
J. Clin. Endocrinol. Metab., Feb;96(2):E243-50 (2011)
Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models.
Hum. Mol. Genet., Mar;20(5):855-66 (2011)
The physiology and biochemistry of adrenarche.
Endocr Dev., 20:20-7 (2011)
Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative.
Int J Pediatr Endocrinol., 2010:275213 (2010)
Primary aldosteronism and a Texas two-step.
Rev Endocr Metab Disord., Mar;12(1):37-42 (2011)
Why human cytochrome P450c21 is a progesterone 21-hydroxylase.
Biochemistry., May;50(19):3968-74 (2011)
Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer.
Proc. Natl. Acad. Sci. U.S.A., Aug;108(33):13728-33 (2011)
Synthesis of halogenated pregnanes, mechanistic probes of steroid hydroxylases CYP17A1 and CYP21A2.
J. Steroid Biochem. Mol. Biol., Jan;128(1-2):38-50 (2012)
Dehydroepiandrosterone replacement therapy--panacea, snake oil, or a bit of both?
Nat Clin Pract Endocrinol Metab., Aug;4(8):442-3 (2008)
Androgens, estrogens, and hydroxysteroid dehydrogenases.
Mol. Cell. Endocrinol., Mar;301(1-2):37-42 (2009)
Mediastinal paragangliomas: association with mutations in the succinate dehydrogenase genes and aggressive behavior.
Endocr. Relat. Cancer., Mar;16(1):291-9 (2009)
Differential effects of chlorthalidone versus spironolactone on muscle sympathetic nerve activity in hypertensive patients.
J. Clin. Endocrinol. Metab., Apr;94(4):1361-6 (2009)
Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.
Mol. Endocrinol., May;23(5):640-8 (2009)
Rapid cortisol assays improve the success rate of adrenal vein sampling for primary aldosteronism.
Ann. Surg., Feb;249(2):318-21 (2009)
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.
Proc. Natl. Acad. Sci. U.S.A., Jun;106(23):9138-43 (2009)
Biochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells.
Endocrinology., Sep;150(9):4154-62 (2009)
Congenital adrenal hyperplasia in adults.
Curr Opin Endocrinol Diabetes Obes., Jun;17(3):210-6 (2010)
What we still do not know about adrenal vein sampling for primary aldosteronism.
Horm. Metab. Res., Jun;42(6):411-5 (2010)
3beta-hydroxysteroid dehydrogenase is a possible pharmacological target in the treatment of castration-resistant prostate cancer.
Endocrinology., Aug;151(8):3514-20 (2010)
46,XX DSD: the masculinised female.
Best Pract. Res. Clin. Endocrinol. Metab., Apr;24(2):219-42 (2010)
Reversible sympathetic overactivity in hypertensive patients with primary aldosteronism.
J. Clin. Endocrinol. Metab., Oct;95(10):4756-61 (2010)
Management of the adult with congenital adrenal hyperplasia.
Int J Pediatr Endocrinol., 2010:614107 (2010)
"Getting from here to there"--mechanisms and limitations to the activation of the androgen receptor in castration-resistant prostate cancer.
J. Investig. Med., Dec;58(8):938-44 (2010)
Epithelial sodium channel allele T594M is not associated with blood pressure or blood pressure response to amiloride.
Hypertension., Mar;47(3):428-33 (2006)
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.
Cell., Mar;124(6):1209-23 (2006)
Associations among androgens, estrogens, and natriuretic peptides in young women: observations from the Dallas Heart Study.
J. Am. Coll. Cardiol., Jan;49(1):109-16 (2007)
Cofactors, redox state, and directional preferences of hydroxysteroid dehydrogenases.
Mol. Cell. Endocrinol., Feb;265-266:83-8 (2007)
Measurement of 18-hydroxycorticosterone during adrenal vein sampling for primary aldosteronism.
J. Clin. Endocrinol. Metab., Jul;92(7):2648-51 (2007)
Basic concepts and recent developments in human steroid hormone biosynthesis.
Rev Endocr Metab Disord., Dec;8(4):289-300 (2007)
Curr Cardiol Rep., Nov;9(6):447-52 (2007)
"Subclinical Cushing's syndrome" is not subclinical: improvement after adrenalectomy in 9 patients.
Surgery., Dec;142(6):900-5; discussion 905.e1 (2007)
Hyperthyroidism-associated coronary vasospasm with myocardial infarction and subsequent euthyroid angina.
Thyroid., Feb;18(2):273-6 (2008)
CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding.
J. Biol. Chem., Dec;278(49):48563-9 (2003)
Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia.
Hum. Mol. Genet., Aug;12(16):1995-2001 (2003)
Clinical implications of androgen synthesis via 5alpha-reduced precursors.
Endocr Dev., 13:55-66 (2008)
Non-traditional metabolic pathways of adrenal steroids.
Rev Endocr Metab Disord., Mar;10(1):27-32 (2009)
5alpha-reduced C21 steroids are substrates for human cytochrome P450c17.
Arch. Biochem. Biophys., Oct;418(2):151-60 (2003)
Steroid 5alpha-reductase 1 promotes 5alpha-androstane-3alpha,17beta-diol synthesis in immature mouse testes by two pathways.
Mol. Cell. Endocrinol., Jul;222(1-2):113-20 (2004)
Human 17beta-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cells.
Arch. Biochem. Biophys., Sep;429(1):50-9 (2004)
Overview of dehydroepiandrosterone biosynthesis.
Semin. Reprod. Med., Nov;22(4):281-8 (2004)
The rise in adrenal androgen biosynthesis: adrenarche.
Semin. Reprod. Med., Nov;22(4):337-47 (2004)
Minireview: cellular redox state regulates hydroxysteroid dehydrogenase activity and intracellular hormone potency.
Endocrinology., Jun;146(6):2531-8 (2005)
Miscellaneous endocrine causes of hypertension.
Curr Cardiol Rep., Nov;7(6):418-24 (2005)
Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues.
Mol. Cell. Endocrinol., Mar;248(1-2):79-86 (2006)
Arginine 276 controls the directional preference of AKR1C9 (rat liver 3alpha-hydroxysteroid dehydrogenase) in human embryonic kidney 293 cells.
Endocrinology., Apr;147(4):1591-7 (2006)
Human cytochrome b5 requires residues E48 and E49 to stimulate the 17,20-lyase activity of cytochrome P450c17.
Biochemistry., Jan;45(3):755-62 (2006)
The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21.
Arch. Biochem. Biophys., Jan;409(1):134-44 (2003)
Towards a unifying mechanism for CYP17 mutations that cause isolated 17,20-lyase deficiency.
Endocr. Res., Nov;28(4):443-7 (2002)
Aldo is back: recent advances and unresolved controversies in hyperaldosteronism.
Curr. Opin. Nephrol. Hypertens., Mar;12(2):153-8 (2003)
Human steroid biosynthesis for the oncologist.
J. Investig. Med., Feb;60(2):495-503 (2012)
Pitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency.
J. Clin. Endocrinol. Metab., Sep;86(9):4416-23 (2001)
Evidence that androgens are the primary steroids produced by Xenopus laevis ovaries and may signal through the classical androgen receptor to promote oocyte maturation.
Proc. Natl. Acad. Sci. U.S.A., Nov;98(24):13728-33 (2001)
A novel point mutation in P450c17 (CYP17) causing combined 17alpha-hydroxylase/17,20-lyase deficiency.
J. Clin. Endocrinol. Metab., Jun;91(6):2428-31 (2006)
Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two Japanese siblings.
Clin. Genet., Jun;73(6):535-44 (2008)
Measurement of 18-hydroxycorticosterone during adrenal vein sampling for primary aldosteronism
Journal of Clinical Endocrinology & Metabolism
Subclinical Cushing Syndrome is not subclinical: improvement after adrenalectomy in 9 patients.
Human cytochrome b5 requires residues E48 and E49 to stimulate the 17, 20-lyase activity of cytochrome P450c17
Arginine 276 Controls the Directional Preference of AKR1C9 (Rat Liver 3alpha-Hydroxysteroid Dehydrogenase) in HEK-293 Cells
Identification of hormonal ligands for the orphan nuclear receptor DAF-12 that govern dauer formation and reproduction in C. elegans