Partners healthcare system
Brigham and womens hospital
Dana farber cancer institute
Umass memorial medical center
Massachusetts General Hospital
Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Biochemistry., Nov;37(47):16465-71 (1998)
The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
J. Biol. Chem., Feb;275(5):3173-8 (2000)
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Proc. Natl. Acad. Sci. U.S.A., Aug;97(16):9299-304 (2000)
FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Neurobiol. Dis., Dec;7(6 Pt B):673-81 (2000)
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.
J. Biol. Chem., Oct;276(43):40288-92 (2001)
Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy.
Neurology., Apr;72(14):1230-5 (2009)
Process improvement methods increase the efficiency, accuracy, and utility of a neurocritical care research repository.
Neurocrit Care., Aug;17(1):90-6 (2012)
Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
J. Neurochem., Aug;75(2):583-93 (2000)
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
Proc. Natl. Acad. Sci. U.S.A., Mar;99(5):2720-5 (2002)
Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation.
J. Biol. Chem., Sep;277(38):35113-7 (2002)
Diffusion-weighted magnetic resonance imaging of bilateral simultaneous optic nerve infarctions.
Arch. Neurol., Jan;66(1):132-3 (2009)
Case records of the Massachusetts General Hospital. Case 8-2009. A 36-year-old woman with headache, hypertension, and seizure 2 weeks post partum.
N. Engl. J. Med., Mar;360(11):1126-37 (2009)