Dr. Andre Nel
Add to your Care-Team
Dr. Andre Nel
Dr. Andre Nel
Internal Medicine - Allergy & Immunology
Los Angeles, CA
Internal Medicine - Allergy & Immunology
In practice for
I am licensed to see patients from
Tumor necrosis factor alpha
200 MEDICAL PLAZA
#365 530 420 120
LOS ANGELES , CA 900950001
Los angeles , CA 90095
4212 MURIETTA AVE
SHERMAN OAKS , CA 914234225
Education and Training
Medical / Graduate School
University of Stellenbosch Faculty of Medicine
Ronald reagan ucla hospital
Ucla neuropsychiatric hospital
Ronald Reagan UCLA Medical Ctr
Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation.
ACS Nano., May;6(5):4349-68 (2012)
High content screening in zebrafish speeds up hazard ranking of transition metal oxide nanoparticles.
ACS Nano., Sep;5(9):7284-95 (2011)
Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism.
ACS Nano., Jun;5(6):4434-47 (2011)
Feasibility of biomarker studies for engineered nanoparticles: what can be learned from air pollution research.
J. Occup. Environ. Med., Jun;53(6 Suppl):S74-9 (2011)
Nanomaterials in the environment: from materials to high-throughput screening to organisms.
ACS Nano., Jan;5(1):13-20 (2011)
Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line.
ACS Nano., Aug;4(8):4539-50 (2010)
Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos.
ACS Nano., Feb;5(2):1223-35 (2011)
Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves.
J. Am. Chem. Soc., Sep;132(36):12690-7 (2010)
Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares.
Am. J. Physiol. Lung Cell Mol. Physiol., Sep;299(3):L374-83 (2010)
Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs.
ACS Nano., Oct;3(10):3273-86 (2009)
Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition.
Environ. Sci. Technol., Aug;43(16):6378-84 (2009)
Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress.
Part Fibre Toxicol., 6:24 (2009)
Mesostructured Silica for Optical Functionality, Nanomachines, and Drug Delivery.
J Am Ceram Soc., Jan;92(s1):s2-s10 (2009)
Adjuvant effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluid.
Proteomics., Feb;10(3):520-31 (2010)
Oxidative stress and asthma: proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluid.
J. Proteome Res., Apr;8(4):1631-8 (2009)
Potential health impact of nanoparticles.
Annu Rev Public Health., 30:137-50 (2009)
The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential.
Environ. Health Perspect., Jul;117(7):1116-23 (2009)
Understanding biophysicochemical interactions at the nano-bio interface.
Nat Mater., Jul;8(7):543-57 (2009)
Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways.
ACS Nano., Jan;2(1):85-96 (2008)
Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery.
ACS Nano., May;2(5):889-96 (2008)
Pro-oxidative DEP chemicals induce heat shock proteins and an unfolding protein response in a bronchial epithelial cell line as determined by DIGE analysis.
Proteomics., Nov;7(21):3906-18 (2007)
Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties.
ACS Nano., Oct;2(10):2121-34 (2008)
Glutathione depletion inhibits dendritic cell maturation and delayed-type hypersensitivity: implications for systemic disease and immunosenescence.
J. Allergy Clin. Immunol., May;119(5):1225-33 (2007)
Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells.
Nanobiotechnology., May;3(2):89-95 (2007)
Importance of oxidative stress in the pathogenesis and treatment of asthma.
Curr Opin Allergy Clin Immunol., Feb;8(1):49-56 (2008)
The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles.
Free Radic. Biol. Med., May;44(9):1689-99 (2008)
Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress.
Circ. Res., Mar;102(5):589-96 (2008)
Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells.
J. Allergy Clin. Immunol., May;121(5):1255-1261.e7 (2008)
Impairment of mitochondrial function by particulate matter (PM) and their toxic components: implications for PM-induced cardiovascular and lung disease.
Front. Biosci., 12:1238-46 (2007)
Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation.
J. Allergy Clin. Immunol., Aug;118(2):455-65 (2006)
Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm.
Nano Lett., Aug;6(8):1794-807 (2006)
Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages.
J. Immunol., Oct;169(8):4531-41 (2002)
Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line.
J. Biol. Chem., Dec;278(50):50781-90 (2003)
Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects.
Clin. Immunol., Dec;109(3):250-65 (2003)
Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals.
J. Immunol., Sep;173(5):3467-81 (2004)
Nitrotyrosine-modified proteins and oxidative stress induced by diesel exhaust particles.
Electrophoresis., Jan;26(1):280-92 (2005)
Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system.
J. Allergy Clin. Immunol., Oct;102(4 Pt 1):539-54 (1998)
Use of a fluorescent phosphoprotein dye to characterize oxidative stress-induced signaling pathway components in macrophage and epithelial cultures exposed to diesel exhaust particle chemicals.
Electrophoresis., Jun;26(11):2092-108 (2005)
The role of phase II antioxidant enzymes in protecting memory T cells from spontaneous apoptosis in young and old mice.
J. Immunol., Sep;175(5):2948-59 (2005)
Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma.
Antioxid. Redox Signal., 8(1-2):88-98 (2006)
Activation of a novel serine/threonine kinase that phosphorylates c-Fos upon stimulation of T and B lymphocytes via antigen and cytokine receptors.
J. Immunol., May;152(9):4347-57 (1994)
Involvement of Janus kinases, p52shc, Raf-1, and MEK-1 in the IL-6-induced mitogen-activated protein kinase cascade of a growth-responsive B cell line.
J. Immunol., Nov;153(10):4436-47 (1994)
Evidence for LFA-1/ICAM-1 dependent stimulation of protein tyrosine phosphorylation in human B lymphoid cell lines during homotypic adhesion.
J. Leukoc. Biol., Feb;57(2):343-51 (1995)
The Jun kinase cascade is responsible for activating the CD28 response element of the IL-2 promoter: proof of cross-talk with the I kappa B kinase cascade.
J. Immunol., Mar;162(6):3176-87 (1999)
Regulation of interleukin-2 transcription by inducible stable expression of dominant negative and dominant active mitogen-activated protein kinase kinase kinase in jurkat T cells. Evidence for the importance of Ras in a pathway that is controlled by dual
J. Biol. Chem., Nov;271(44):27366-73 (1996)
Involvement of Stat3 in interleukin-6-induced IgM production in a human B-cell line.
Immunology., Mar;90(3):350-7 (1997)
An update on the immunopathogenesis of asthma as an inflammatory disease enhanced by environmental pollutants.
Allergy Asthma Proc., 18(4):227-33 (1997)
Inflammatory cytokines induce the expression of basic fibroblast growth factor (bFGF) isoforms required for the growth of Kaposi's sarcoma and endothelial cells through the activation of AP-1 response elements in the bFGF promoter.
AIDS., Jan;12(1):19-27 (1998)
Activation of the human RANTES gene promoter in a macrophage cell line by lipopolysaccharide is dependent on stress-activated protein kinases and the IkappaB kinase cascade: implications for exacerbation of allergic inflammation by environmental pollutant
Clin. Immunol., Mar;90(3):287-301 (1999)
Primary human CD4+ T cells contain heterogeneous I kappa B kinase complexes: role in activation of the IL-2 promoter.
J. Immunol., Nov;163(10):5444-52 (1999)
Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages.
J. Immunol., Nov;163(10):5582-91 (1999)
The NF-kappa B cascade is important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes.
J. Immunol., Aug;165(4):1743-54 (2000)
The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles.
J. Immunol., Sep;165(5):2703-11 (2000)
The physical association of protein kinase C theta with a lipid raft-associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and CD28.
J. Immunol., Dec;165(12):6933-40 (2000)
Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization.
J. Immunol., Mar;168(5):2560-7 (2002)
Protein kinase D is a downstream target of protein kinase Ctheta.
Biochem. Biophys. Res. Commun., Mar;291(3):444-52 (2002)
The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress.
Curr Opin Pulm Med., Jan;7(1):20-6 (2001)
T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse.
J. Allergy Clin. Immunol., May;109(5):758-70 (2002)
T-cell activation through the antigen receptor. Part 2: role of signaling cascades in T-cell differentiation, anergy, immune senescence, and development of immunotherapy.
J. Allergy Clin. Immunol., Jun;109(6):901-15 (2002)
Stimulation of MAP-2 kinase activity in T lymphocytes by anti-CD3 or anti-Ti monoclonal antibody is partially dependent on protein kinase C.
J. Immunol., Apr;144(7):2683-9 (1990)
CD-3-mediated activation of MAP-2 kinase can be modified by ligation of the CD4 receptor. Evidence for tyrosine phosphorylation during activation of this kinase.
J. Immunol., Aug;145(3):971-9 (1990)
Activation of MAP-2 kinase activity by the CD2 receptor in Jurkat T cells can be reversed by CD45 phosphatase.
Immunology., Jun;73(2):129-33 (1991)
Protein kinase C plays a role in the induction of tyrosine phosphorylation of lymphoid microtubule-associated protein-2 kinase. Evidence for a CD3-associated cascade that includes pp56lck and that is defective in HPB-ALL.
J. Immunol., Sep;147(6):1933-9 (1991)
Evidence for involvement of glycoprotein-CD45 phosphatase in reversing glycoprotein-CD3-induced microtubule-associated protein-2 kinase activity in Jurkat T-cells.
Biochem. J., Jun;276 ( Pt 2):481-5 (1991)
Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetate.
Biochem. J., Mar;290 ( Pt 2):545-50 (1993)
Stimulation of B-cells via the membrane immunoglobulin receptor or with phorbol myristate 13-acetate induces tyrosine phosphorylation and activation of a 42-kDa microtubule-associated protein-2 kinase.
J. Biol. Chem., Oct;266(28):19088-94 (1991)
Activation of mitogen-activated protein kinase/ERK-2 in phytohaemagglutin in blasts by recombinant interleukin-2: contrasting features with CD3 activation.
Immunology., May;79(1):112-8 (1993)
Contrasting effects of two tumour promoters, phorbol myristate acetate and okadaic acid, on T-cell responses and activation of p42 MAP-kinase/ERK-2.
Immunology., May;79(1):24-31 (1993)
Fas activates the JNK pathway in human colonic epithelial cells: lack of a direct role in apoptosis.
Am. J. Physiol., Mar;276(3 Pt 1):G599-605 (1999)
Recombinant IL-6 activates p42 and p44 mitogen-activated protein kinases in the IL-6 responsive B cell line, AF-10.
J. Immunol., Jun;150(11):4743-53 (1993)
Oncostatin-M stimulates tyrosine protein phosphorylation in parallel with the activation of p42MAPK/ERK-2 in Kaposi's cells. Evidence that this pathway is important in Kaposi cell growth.
J. Clin. Invest., Aug;92(2):848-57 (1993)
Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR.
J. Biol. Chem., Aug;270(31):18428-36 (1995)
Differential activation of the extracellular signal-regulated kinase, Jun kinase and Janus kinase-Stat pathways by oncostatin M and basic fibroblast growth factor in AIDS-derived Kaposi's sarcoma cells.
AIDS., Apr;10(4):369-78 (1996)
The University of California Center for the Environmental Implications of Nanotechnology.
Environ. Sci. Technol., Sep;43(17):6453-7 (2009)
T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets.
J. Allergy Clin. Immunol., Apr;121(4):812-23; quiz 824-5 (2008)
Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization.
J. Allergy Clin. Immunol., Sep;122(3):595-602.e5 (2008)
Tracheobronchial particle dose considerations for in vitro toxicology studies.
Toxicol. Sci., Jul;92(1):126-32 (2006)
Dr. Andre Nel M