Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation.
Endocrinology., Jul;150(7):3177-85 (2009)
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Endocrinol. Metab. Clin. North Am., Mar;37(1):1-22, vii (2008)
Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.
J. Clin. Endocrinol. Metab., Dec;91(12):4792-7 (2006)
Pituitary tumor enlargement in two patients with acromegaly during pegvisomant therapy.
Pituitary., 10(3):283-9 (2007)
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Pediatr Endocrinol Rev., Jun;4(4):335-42 (2007)
Expression analysis of hypothalamic and pituitary components of the growth hormone axis in fasted and streptozotocin-treated neuropeptide Y (NPY)-intact (NPY+/+) and NPY-knockout (NPY-/-) mice.
Neuroendocrinology., 81(6):360-71 (2005)
Tumor deletion mapping on chromosome 11q13 in eight families with isolated familial somatotropinoma and in 15 sporadic somatotropinomas.
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Endocrinology., Mar;142(3):1117-23 (2001)
The effect of GHRH on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling.
Endocrinology., Sep;142(9):3764-73 (2001)
Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis.
Trends Endocrinol. Metab., Sep;13(7):299-303 (2002)
Hypothalamic/pituitary-axis of the spontaneous dwarf rat: autofeedback regulation of growth hormone (GH) includes suppression of GH releasing-hormone receptor messenger ribonucleic acid.
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Growth hormone-dependent regulation of pituitary GH secretagogue receptor (GHS-R) mRNA levels in the spontaneous dwarf Rat.
Neuroendocrinology., Nov;68(5):312-8 (1998)
Loss of heterozygosity on chromosome 11q13 in two families with acromegaly/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene.
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Growth hormone-releasing hormone receptor (GHRH-R) and growth hormone secretagogue receptor (GHS-R) mRNA levels during postnatal development in male and female rats.
J. Neuroendocrinol., Apr;11(4):299-306 (1999)
Growth hormone (GH)-releasing hormone (GHRH) and the GH secretagogue (GHS), L692,585, differentially modulate rat pituitary GHS receptor and GHRH receptor messenger ribonucleic acid levels.
Endocrinology., Aug;140(8):3581-6 (1999)
Isolated familial somatotropinomas: establishment of linkage to chromosome 11q13.1-11q13.3 and evidence for a potential second locus at chromosome 2p16-12.
J. Clin. Endocrinol. Metab., Feb;85(2):707-14 (2000)
p27Kip1-deficient mice exhibit accelerated growth hormone-releasing hormone (GHRH)-induced somatotrope proliferation and adenoma formation.
Oncogene., Apr;19(15):1875-84 (2000)
Modulation of pituitary somatostatin receptor subtype (sst1-5) messenger ribonucleic acid levels by changes in the growth hormone axis.
Endocrinology., Oct;141(10):3556-63 (2000)
Secretagogues and the somatotrope: signaling and proliferation.
Recent Prog. Horm. Res., 55:269-90; discussion 290-1 (2000)
The tyrosine hydroxylase-human growth hormone (GH) transgenic mouse as a model of hypothalamic GH deficiency: growth retardation is the result of a selective reduction in somatotrope numbers despite normal somatotrope function.
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Homologous down-regulation of growth hormone-releasing hormone receptor messenger ribonucleic acid levels.
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Expression of a fusion gene consisting of the mouse growth hormone-releasing hormone gene promoter linked to the SV40 T-antigen gene in transgenic mice.
Mol. Cell. Endocrinol., Feb;137(2):161-8 (1998)
Discordant effects of endogenous and exogenous somatostatin on growth hormone-releasing hormone secretion from perifused mouse hypothalami.
Neuroendocrinology., May;61(5):566-72 (1995)
Autofeedback suppression of growth hormone (GH) secretion in transgenic mice expressing a human GH reporter targeted by tyrosine hydroxylase 5'-flanking sequences to the hypothalamus.
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Consensus statement: medical management of acromegaly.
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Increase in mRNA concentrations of pituitary receptors for growth hormone-releasing hormone and growth hormone secretagogues after neonatal monosodium glutamate treatment.
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Acromegaly and Cushing's syndrome due to ectopic production of GHRH and ACTH by a thymic carcinoid tumour: in vitro responses to GHRH and GHRP-6.
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Role of growth hormone (GH)-releasing hormone and somatostatin on leptin-induced GH secretion.
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Growth hormone-releasing factor analogs with hydrophobic residues at position 19. Effects on growth hormone releasing activity in vitro and in vivo, stability in blood plasma in vitro, and secondary structure.
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Inhibitory effects of ethanol on the growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-I axis in the rat.
Endocrinology., Dec;131(6):2603-8 (1992)
Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation.
J. Clin. Endocrinol. Metab., Jan;76(1):216-22 (1993)
Effects of drinking water monochloramine on lipid and thyroid metabolism in healthy men.
Environ. Health Perspect., Mar;99:369-74 (1993)
Lack of effect of drinking water chlorine on lipid and thyroid metabolism in healthy humans.
Environ. Health Perspect., Mar;99:375-81 (1993)
Differential sensitivity of growth hormone-releasing hormone and somatostatin release from perifused mouse hypothalamic fragments in response to glucose deficiency.
Neuroendocrinology., Jun;57(6):1097-105 (1993)
Mouse hypothalamic growth hormone-releasing hormone and somatostatin responses to probes of signal transduction systems.
Peptides., 14(4):671-7 (1993)
Stimulatory effect of thyroid hormone on growth hormone gene expression in a human pituitary cell line.
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Differential effects of central and peripheral administration of growth hormone (GH) and insulin-like growth factor on hypothalamic GH-releasing hormone and somatostatin gene expression in GH-deficient dwarf rats.
Endocrinology., Aug;133(2):793-9 (1993)
Obesity-associated decrease in growth hormone-releasing hormone gene expression: a mechanism for reduced growth hormone mRNA levels in genetically obese Zucker rats.
Neuroendocrinology., Sep;58(3):332-7 (1993)
Impaired growth hormone-releasing hormone signal transduction in the dwarf (dw) rat is independent of a generalized defect in the stimulatory G-protein, Gs alpha.
Endocrinology., Dec;133(6):2782-6 (1993)
Development of neuroepithelial tumors of the adrenal medulla in transgenic mice expressing a mouse hypothalamic growth hormone-releasing hormone promoter-simian virus-40 T-antigen fusion gene.
Endocrinology., Mar;134(3):1219-24 (1994)
Somatotroph hyperplasia without pituitary adenoma associated with a long standing growth hormone-releasing hormone-producing bronchial carcinoid.
J. Clin. Endocrinol. Metab., Mar;78(3):555-60 (1994)
Acromegaly: what constitutes optimal therapy?
J. Clin. Endocrinol. Metab., Feb;81(2):443-5 (1996)
Growth hormone-releasing hormone immunoreactivity in mouse placenta, maternal blood, and amniotic fluid: molecular characterization and secretion from primary cell cultures in vitro.
Endocrinology., Apr;136(4):1731-6 (1995)
Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).
Cell., May;85(5):721-32 (1996)
Suppression of growth hormone (GH) hypersecretion due to ectopic GH-releasing hormone (GHRH) by a selective GHRH antagonist.
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Effects of antagonists of growth hormone-releasing hormone (GHRH) on GH and insulin-like growth factor I levels in transgenic mice overexpressing the human GHRH gene, an animal model of acromegaly.
Endocrinology., Nov;138(11):4536-42 (1997)
Morphologic effects of hGRH gene expression on the pituitary, liver, and pancreas of MT-hGRH transgenic mice. An in situ hybridization analysis.
Am. J. Pathol., Oct;141(4):895-906 (1992)
Regulation of growth hormone secretion.
Front Neuroendocrinol., Oct;13(4):344-405 (1992)
Interaction of ethanol with signal transduction mechanisms mediating growth hormone release by rat pituitary cells in vitro.
Endocrinology., Jul;131(1):173-80 (1992)
Biosynthesis of human growth hormone-releasing hormone (hGRH) in the pituitary of hGRH transgenic mice.
Endocrinology., Dec;129(6):3274-80 (1991)
Synthesis and biological evaluation of mouse growth hormone-releasing factor.
Int. J. Pept. Protein Res., Jun;37(6):552-5 (1991)
Evidence for a defect in growth hormone-releasing factor signal transduction in the dwarf (dw/dw) rat pituitary.
Endocrinology., Jul;129(1):58-67 (1991)
Growth hormone and insulin-like growth factor-I measurements in high growth (hg) mice.
Genet. Res., Aug;58(1):67-74 (1991)
Impaired generation of cyclic adenosine 3',5'-monophosphate in a somatomammotroph cell line derived from dwarf (dw) rat anterior pituitaries.
Endocrinology., Dec;129(6):3410-6 (1991)
Clinical review 22: Therapeutic options in acromegaly.
J. Clin. Endocrinol. Metab., Jun;72(6):1175-81 (1991)
The role of the cholinergic pathway in growth hormone feedback.
J. Clin. Endocrinol. Metab., May;72(5):1081-7 (1991)
Tissue-specific transcription initiation and effects of growth hormone (GH) deficiency on the regulation of mouse and rat GH-releasing hormone gene in hypothalamus and placenta.
Mol. Endocrinol., Apr;5(4):476-84 (1991)
Somatostatin secretion and action in the regulation of growth hormone secretion.
Metab. Clin. Exp., Sep;39(9 Suppl 2):43-5 (1990)
Tissue distribution and molecular heterogeneity of human growth hormone-releasing factor in the transgenic mouse.
Endocrinology., Nov;127(5):2149-56 (1990)
A comparison of transcriptional regulatory element activities in transformed and non-transformed rat anterior pituitary cells.
Mol. Cell. Endocrinol., Feb;75(2):91-100 (1991)
Alterations in circulating human chorionic gonadotropin free alpha-subunit in insulin-dependent diabetic pregnancy: correlation with maternal characteristics.
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Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep. Spontaneous secretion and response to insulin-induced hypoglycemia.
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Impaired inhibitory effects of somatostatin on growth hormone (GH)-releasing hormone stimulation of GH secretion after short term infusion.
J. Clin. Endocrinol. Metab., Jul;71(1):157-63 (1990)
Growth hormone and prolactin secretion in cultured somatomammotroph cells.
Endocrinology., Sep;127(3):1129-35 (1990)
Expression of a cytomegalovirus-human growth hormone-releasing hormone precursor fusion gene in transfected GH3 cells.
Mol. Cell. Endocrinol., Jun;71(2):105-15 (1990)
Lack of effect of drinking water barium on cardiovascular risk factors.
Environ. Health Perspect., Apr;85:355-9 (1990)
Effects of thyroid hormone deficiency and replacement on rat hypothalamic growth hormone (GH)-releasing hormone gene expression in vivo are mediated by GH.
Mol. Endocrinol., Mar;4(3):402-8 (1990)
Growth hormone-releasing hormone: structure, gene expression and molecular heterogeneity.
Acta Paediatr Scand Suppl., 367:81-6 (1990)
Beta-adrenergic modulation of growth hormone (GH) autofeedback on sleep-associated and pharmacologically induced GH secretion.
J. Clin. Endocrinol. Metab., Dec;69(6):1187-94 (1989)
Regulation of growth hormone-releasing hormone gene expression and biosynthesis.
Yale J Biol Med., 62(5):427-33 (1989)
Comparison of radio-frequency and electrolytic lesions of the paraventricular hypothalamic nucleus.
Physiol. Behav., Aug;46(2):321-5 (1989)
Immunohistochemical analysis of human growth hormone-releasing hormone gene expression in transgenic mice.
Endocrinology., Aug;125(2):801-9 (1989)
Dipeptidylpeptidase IV and trypsin-like enzymatic degradation of human growth hormone-releasing hormone in plasma.
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Cloning and characterization of mouse growth hormone-releasing hormone (GRH) complementary DNA: increased GRH messenger RNA levels in the growth hormone-deficient lit/lit mouse.
Mol. Endocrinol., Oct;3(10):1529-36 (1989)
Hypothalamic obesity: comparison of radio-frequency and electrolytic lesions in weanling rats.
Physiol. Behav., Jan;45(1):127-32 (1989)
Production of transgenic sheep with growth-regulating genes.
Mol. Reprod. Dev., 1(3):164-9 (1989)
Growth hormone enhances hepatic epidermal growth factor receptor concentration in mice.
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