Dr. Lawrence Frohman
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Dr. Lawrence Frohman
Dr. Lawrence Frohman
I specialize in
I have been in practice
I'm known for
Adrenal gland disorders
My answers and insights have
Helped 13,535 people
Received 2 doctor agrees
Received 6 thanks
Here are kind words from others
Dr. Frohman is an amazing doctor! #nationaldoctorsday2015 #virtualflower1
Dr. Frohman is an amazing doctor! #nationaldoctorsday2015 #virtualflower1
I was educated and trained at
Medical / Graduate School
University of Michigan Medical School, MI
I'm affiliated with
University of illinois med center at chicago
University Of Illinois Med Ctr
Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation.
Endocrinology., Jul;150(7):3177-85 (2009)
Normal physiology of hypothalamic pituitary regulation.
Endocrinol. Metab. Clin. North Am., Mar;37(1):1-22, vii (2008)
Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.
J. Clin. Endocrinol. Metab., Dec;91(12):4792-7 (2006)
Pituitary tumor enlargement in two patients with acromegaly during pegvisomant therapy.
Pituitary., 10(3):283-9 (2007)
The empty sella.
Pediatr Endocrinol Rev., Jun;4(4):335-42 (2007)
Expression analysis of hypothalamic and pituitary components of the growth hormone axis in fasted and streptozotocin-treated neuropeptide Y (NPY)-intact (NPY+/+) and NPY-knockout (NPY-/-) mice.
Neuroendocrinology., 81(6):360-71 (2005)
Tumor deletion mapping on chromosome 11q13 in eight families with isolated familial somatotropinoma and in 15 sporadic somatotropinomas.
J. Clin. Endocrinol. Metab., Dec;90(12):6580-7 (2005)
Isolated familial somatotropinomas: clinical and genetic considerations.
Trans. Am. Clin. Climatol. Assoc., 114:165-77 (2003)
Growth Horm. IGF Res., Jun;14 Suppl A:S90-6 (2004)
Isolated familial somatotropinoma.
Pituitary., 7(2):95-101 (2004)
Growth hormone-releasing hormone and pituitary somatotrope proliferation.
Minerva Endocrinol., Dec;27(4):277-85 (2002)
The growth hormone (GH)-axis of GH receptor/binding protein gene-disrupted and metallothionein-human GH-releasing hormone transgenic mice: hypothalamic neuropeptide and pituitary receptor expression in the absence and presence of GH feedback.
Endocrinology., Mar;142(3):1117-23 (2001)
The effect of GHRH on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling.
Endocrinology., Sep;142(9):3764-73 (2001)
Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis.
Trends Endocrinol. Metab., Sep;13(7):299-303 (2002)
Hypothalamic/pituitary-axis of the spontaneous dwarf rat: autofeedback regulation of growth hormone (GH) includes suppression of GH releasing-hormone receptor messenger ribonucleic acid.
Endocrinology., Aug;139(8):3554-60 (1998)
Growth hormone-dependent regulation of pituitary GH secretagogue receptor (GHS-R) mRNA levels in the spontaneous dwarf Rat.
Neuroendocrinology., Nov;68(5):312-8 (1998)
Loss of heterozygosity on chromosome 11q13 in two families with acromegaly/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene.
J. Clin. Endocrinol. Metab., Jan;84(1):249-56 (1999)
Growth hormone-releasing hormone receptor (GHRH-R) and growth hormone secretagogue receptor (GHS-R) mRNA levels during postnatal development in male and female rats.
J. Neuroendocrinol., Apr;11(4):299-306 (1999)
Growth hormone (GH)-releasing hormone (GHRH) and the GH secretagogue (GHS), L692,585, differentially modulate rat pituitary GHS receptor and GHRH receptor messenger ribonucleic acid levels.
Endocrinology., Aug;140(8):3581-6 (1999)
Isolated familial somatotropinomas: establishment of linkage to chromosome 11q13.1-11q13.3 and evidence for a potential second locus at chromosome 2p16-12.
J. Clin. Endocrinol. Metab., Feb;85(2):707-14 (2000)
p27Kip1-deficient mice exhibit accelerated growth hormone-releasing hormone (GHRH)-induced somatotrope proliferation and adenoma formation.
Oncogene., Apr;19(15):1875-84 (2000)
Modulation of pituitary somatostatin receptor subtype (sst1-5) messenger ribonucleic acid levels by changes in the growth hormone axis.
Endocrinology., Oct;141(10):3556-63 (2000)
Secretagogues and the somatotrope: signaling and proliferation.
Recent Prog. Horm. Res., 55:269-90; discussion 290-1 (2000)
The tyrosine hydroxylase-human growth hormone (GH) transgenic mouse as a model of hypothalamic GH deficiency: growth retardation is the result of a selective reduction in somatotrope numbers despite normal somatotrope function.
Endocrinology., Nov;137(11):4630-6 (1996)
Homologous down-regulation of growth hormone-releasing hormone receptor messenger ribonucleic acid levels.
Endocrinology., Mar;138(3):1058-65 (1997)
Expression of a fusion gene consisting of the mouse growth hormone-releasing hormone gene promoter linked to the SV40 T-antigen gene in transgenic mice.
Mol. Cell. Endocrinol., Feb;137(2):161-8 (1998)
Discordant effects of endogenous and exogenous somatostatin on growth hormone-releasing hormone secretion from perifused mouse hypothalami.
Neuroendocrinology., May;61(5):566-72 (1995)
Autofeedback suppression of growth hormone (GH) secretion in transgenic mice expressing a human GH reporter targeted by tyrosine hydroxylase 5'-flanking sequences to the hypothalamus.
Endocrinology., Sep;136(9):4044-8 (1995)
Growth hormone physiology in health and disease: insights using genetic and transgenic models.
J. Pediatr. Endocrinol. Metab., Jun;9 Suppl 3:233-6 (1996)
New insights into the regulation of somatotrope function using genetic and transgenic models.
Metab. Clin. Exp., Aug;45(8 Suppl 1):1-3 (1996)
Hypersecretion of growth hormone and prolactin in McCune-Albright syndrome.
J. Clin. Endocrinol. Metab., Jun;68(6):1148-54 (1989)
A neuroendocrine overview of aging.
Neurobiol. Aging., 15(4):479-84 (1994)
Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial.
J. Clin. Endocrinol. Metab., Jan;94(1):115-22 (2009)
Consensus statement: medical management of acromegaly.
Eur. J. Endocrinol., Dec;153(6):737-40 (2005)
Diagnosis and treatment of acromegaly complications.
J. Endocrinol. Invest., Dec;26(12):1242-7 (2003)
Glucocorticoids regulate pituitary growth hormone secretagogue receptor gene expression.
J. Neuroendocrinol., Jun;12(6):481-5 (2000)
Increase in mRNA concentrations of pituitary receptors for growth hormone-releasing hormone and growth hormone secretagogues after neonatal monosodium glutamate treatment.
J. Neuroendocrinol., Apr;12(4):335-41 (2000)
Acromegaly and Cushing's syndrome due to ectopic production of GHRH and ACTH by a thymic carcinoid tumour: in vitro responses to GHRH and GHRP-6.
Clin. Endocrinol. (Oxf)., Feb;48(2):243-50 (1998)
Role of growth hormone (GH)-releasing hormone and somatostatin on leptin-induced GH secretion.
Neuroendocrinology., Jan;69(1):3-10 (1999)
Growth hormone-releasing factor analogs with hydrophobic residues at position 19. Effects on growth hormone releasing activity in vitro and in vivo, stability in blood plasma in vitro, and secondary structure.
J. Med. Chem., Oct;35(21):3928-33 (1992)
Inhibitory effects of ethanol on the growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-I axis in the rat.
Endocrinology., Dec;131(6):2603-8 (1992)
Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation.
J. Clin. Endocrinol. Metab., Jan;76(1):216-22 (1993)
Effects of drinking water monochloramine on lipid and thyroid metabolism in healthy men.
Environ. Health Perspect., Mar;99:369-74 (1993)
Lack of effect of drinking water chlorine on lipid and thyroid metabolism in healthy humans.
Environ. Health Perspect., Mar;99:375-81 (1993)
Differential sensitivity of growth hormone-releasing hormone and somatostatin release from perifused mouse hypothalamic fragments in response to glucose deficiency.
Neuroendocrinology., Jun;57(6):1097-105 (1993)
Mouse hypothalamic growth hormone-releasing hormone and somatostatin responses to probes of signal transduction systems.
Peptides., 14(4):671-7 (1993)
Stimulatory effect of thyroid hormone on growth hormone gene expression in a human pituitary cell line.
J. Clin. Endocrinol. Metab., Jul;77(1):281-5 (1993)
Differential effects of central and peripheral administration of growth hormone (GH) and insulin-like growth factor on hypothalamic GH-releasing hormone and somatostatin gene expression in GH-deficient dwarf rats.
Endocrinology., Aug;133(2):793-9 (1993)
Obesity-associated decrease in growth hormone-releasing hormone gene expression: a mechanism for reduced growth hormone mRNA levels in genetically obese Zucker rats.
Neuroendocrinology., Sep;58(3):332-7 (1993)
Impaired growth hormone-releasing hormone signal transduction in the dwarf (dw) rat is independent of a generalized defect in the stimulatory G-protein, Gs alpha.
Endocrinology., Dec;133(6):2782-6 (1993)
Development of neuroepithelial tumors of the adrenal medulla in transgenic mice expressing a mouse hypothalamic growth hormone-releasing hormone promoter-simian virus-40 T-antigen fusion gene.
Endocrinology., Mar;134(3):1219-24 (1994)
Somatotroph hyperplasia without pituitary adenoma associated with a long standing growth hormone-releasing hormone-producing bronchial carcinoid.
J. Clin. Endocrinol. Metab., Mar;78(3):555-60 (1994)
Acromegaly: what constitutes optimal therapy?
J. Clin. Endocrinol. Metab., Feb;81(2):443-5 (1996)
Growth hormone-releasing hormone immunoreactivity in mouse placenta, maternal blood, and amniotic fluid: molecular characterization and secretion from primary cell cultures in vitro.
Endocrinology., Apr;136(4):1731-6 (1995)
Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).
Cell., May;85(5):721-32 (1996)
Suppression of growth hormone (GH) hypersecretion due to ectopic GH-releasing hormone (GHRH) by a selective GHRH antagonist.
J. Clin. Endocrinol. Metab., Feb;82(2):634-7 (1997)
Effects of antagonists of growth hormone-releasing hormone (GHRH) on GH and insulin-like growth factor I levels in transgenic mice overexpressing the human GHRH gene, an animal model of acromegaly.
Endocrinology., Nov;138(11):4536-42 (1997)
Morphologic effects of hGRH gene expression on the pituitary, liver, and pancreas of MT-hGRH transgenic mice. An in situ hybridization analysis.
Am. J. Pathol., Oct;141(4):895-906 (1992)
Regulation of growth hormone secretion.
Front Neuroendocrinol., Oct;13(4):344-405 (1992)
Interaction of ethanol with signal transduction mechanisms mediating growth hormone release by rat pituitary cells in vitro.
Endocrinology., Jul;131(1):173-80 (1992)
Biosynthesis of human growth hormone-releasing hormone (hGRH) in the pituitary of hGRH transgenic mice.
Endocrinology., Dec;129(6):3274-80 (1991)
Synthesis and biological evaluation of mouse growth hormone-releasing factor.
Int. J. Pept. Protein Res., Jun;37(6):552-5 (1991)
Evidence for a defect in growth hormone-releasing factor signal transduction in the dwarf (dw/dw) rat pituitary.
Endocrinology., Jul;129(1):58-67 (1991)
Growth hormone and insulin-like growth factor-I measurements in high growth (hg) mice.
Genet. Res., Aug;58(1):67-74 (1991)
Impaired generation of cyclic adenosine 3',5'-monophosphate in a somatomammotroph cell line derived from dwarf (dw) rat anterior pituitaries.
Endocrinology., Dec;129(6):3410-6 (1991)
Clinical review 22: Therapeutic options in acromegaly.
J. Clin. Endocrinol. Metab., Jun;72(6):1175-81 (1991)
The role of the cholinergic pathway in growth hormone feedback.
J. Clin. Endocrinol. Metab., May;72(5):1081-7 (1991)
Tissue-specific transcription initiation and effects of growth hormone (GH) deficiency on the regulation of mouse and rat GH-releasing hormone gene in hypothalamus and placenta.
Mol. Endocrinol., Apr;5(4):476-84 (1991)
Somatostatin secretion and action in the regulation of growth hormone secretion.
Metab. Clin. Exp., Sep;39(9 Suppl 2):43-5 (1990)
Tissue distribution and molecular heterogeneity of human growth hormone-releasing factor in the transgenic mouse.
Endocrinology., Nov;127(5):2149-56 (1990)
A comparison of transcriptional regulatory element activities in transformed and non-transformed rat anterior pituitary cells.
Mol. Cell. Endocrinol., Feb;75(2):91-100 (1991)
Alterations in circulating human chorionic gonadotropin free alpha-subunit in insulin-dependent diabetic pregnancy: correlation with maternal characteristics.
J. Clin. Endocrinol. Metab., Jul;71(1):46-52 (1990)
Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep. Spontaneous secretion and response to insulin-induced hypoglycemia.
J. Clin. Invest., Jul;86(1):17-24 (1990)
Impaired inhibitory effects of somatostatin on growth hormone (GH)-releasing hormone stimulation of GH secretion after short term infusion.
J. Clin. Endocrinol. Metab., Jul;71(1):157-63 (1990)
Growth hormone and prolactin secretion in cultured somatomammotroph cells.
Endocrinology., Sep;127(3):1129-35 (1990)
Expression of a cytomegalovirus-human growth hormone-releasing hormone precursor fusion gene in transfected GH3 cells.
Mol. Cell. Endocrinol., Jun;71(2):105-15 (1990)
Lack of effect of drinking water barium on cardiovascular risk factors.
Environ. Health Perspect., Apr;85:355-9 (1990)
Effects of thyroid hormone deficiency and replacement on rat hypothalamic growth hormone (GH)-releasing hormone gene expression in vivo are mediated by GH.
Mol. Endocrinol., Mar;4(3):402-8 (1990)
Growth hormone-releasing hormone: structure, gene expression and molecular heterogeneity.
Acta Paediatr Scand Suppl., 367:81-6 (1990)
Beta-adrenergic modulation of growth hormone (GH) autofeedback on sleep-associated and pharmacologically induced GH secretion.
J. Clin. Endocrinol. Metab., Dec;69(6):1187-94 (1989)
Regulation of growth hormone-releasing hormone gene expression and biosynthesis.
Yale J Biol Med., 62(5):427-33 (1989)
Comparison of radio-frequency and electrolytic lesions of the paraventricular hypothalamic nucleus.
Physiol. Behav., Aug;46(2):321-5 (1989)
Immunohistochemical analysis of human growth hormone-releasing hormone gene expression in transgenic mice.
Endocrinology., Aug;125(2):801-9 (1989)
Dipeptidylpeptidase IV and trypsin-like enzymatic degradation of human growth hormone-releasing hormone in plasma.
J. Clin. Invest., May;83(5):1533-40 (1989)
Cloning and characterization of mouse growth hormone-releasing hormone (GRH) complementary DNA: increased GRH messenger RNA levels in the growth hormone-deficient lit/lit mouse.
Mol. Endocrinol., Oct;3(10):1529-36 (1989)
Hypothalamic obesity: comparison of radio-frequency and electrolytic lesions in weanling rats.
Physiol. Behav., Jan;45(1):127-32 (1989)
Production of transgenic sheep with growth-regulating genes.
Mol. Reprod. Dev., 1(3):164-9 (1989)
Growth hormone enhances hepatic epidermal growth factor receptor concentration in mice.
J. Clin. Invest., Dec;82(6):1871-6 (1988)
Dr. Lawrence Frohman M
Why does increased leucorreah occur after intercourse? Is it bad? In brief: NoLEUKORRHEASee 1 more answer
Some women experience this and it may reflect vaginal irritation.
How do I get rid of dull ache lower left abdomen is it gas? In brief: Probably not
Dull and constant aching is unlikely to be gas.
Need to know what is causing it - if it persists, see your doctor.
How to prevent nausea while taking tinidazole? I want to be able to keep it down! In brief: No sure fire methodNAUSEA TINIDAZOLE
Nothing works that well. However, taking the pill with food may help.
Can buldging discs in the lumbar cause pain that wraps around to the abdomen? In brief: NoSee 1 more answer
Pain may go down the legs.
I have been on Depo-Provera for 6 years i just got off of it in october im trying to get pregnant and im very stressed. Is there a pill i can take? In brief: NoSTRESS PREGNANCY
Better off not taking any meds.
What are normal FSH & estradiol levels before ovulation and after ovulation? Can a blood test checking these levels indicate if ovulation has occured? In brief: NoSee 1 more answer
They vary with time before ovulation.
Checking a Progesterone level after ovulation is a better way to answer the question.ESTRACE ESTRADIOL LEVEL FSH GYNODIOL OVULATION FEMALE HEALTH
Could you tell me what type of effects would anorexia pose to a growing girl? In brief: Delayed menarcheANOREXIA (NERVOSA) SUDDEN CARDIAC DEATH OSTEOPOROSIS GIRL
Menstrual period onset may be delayed bone growth and strength may occur, leading to a risk of osteoporosis.