Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.
Blood., Feb;119(8):1872-81 (2012)
mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues.
Br. J. Haematol., Feb;152(3):307-21 (2011)
Infant leukemia 2010: a call to action for the west and the "four Asian Tigers".
Pediatr Blood Cancer., Dec;55(7):1247-9 (2010)
Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia.
Blood., Jan;115(2):326-30 (2010)
A safer regimen for high-risk neuroblastoma.
Pediatr Blood Cancer., Jul;53(1):3-6 (2009)
Panhandle PCR approaches to cloning MLL genomic breakpoint junctions and fusion transcript sequences.
Methods Mol. Biol., 538:85-114 (2009)
Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis.
Blood., Oct;112(8):3383-90 (2008)
Abundant anti-apoptotic BCL-2 is a molecular target in leukaemias with t(4;11) translocation.
Br. J. Haematol., Jun;141(6):827-39 (2008)
Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome.
Blood., Apr;111(7):3802-12 (2008)
Characterization of an etoposide-glutathione conjugate derived from metabolic activation by human cytochrome p450.
Curr. Drug Metab., Dec;7(8):897-911 (2006)
Proteomics-based strategy to identify biomarkers and pharmacological targets in leukemias with t(4;11) translocations.
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Maternal hemoglobin concentration during pregnancy and risk of infant leukaemia: a children's oncology group study.
Br. J. Cancer., Nov;95(9):1274-6 (2006)
Topoisomerase II and the etiology of chromosomal translocations.
DNA Repair (Amst.)., Sep;5(9-10):1093-108 (2006)
BglII-based panhandle and reverse panhandle PCR approaches increase capability for cloning der(II) and der(other) genomic breakpoint junctions of MLL translocations.
Genes Chromosomes Cancer., Aug;45(8):740-53 (2006)
Development of cold agglutinin autoimmune hemolytic anemia during treatment for pediatric acute lymphoblastic leukemia.
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DNA topoisomerase II in therapy-related acute promyelocytic leukemia.
N. Engl. J. Med., Apr;352(15):1529-38 (2005)
Maternal diet and infant leukemia: the DNA topoisomerase II inhibitor hypothesis: a report from the children's oncology group.
Cancer Epidemiol. Biomarkers Prev., Mar;14(3):651-5 (2005)
The molecular basis of leukemia.
Hematology Am Soc Hematol Educ Program., 80-97 (2004)
Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion.
Blood., Mar;105(5):2124-31 (2005)
Kinetics and regulation of cytochrome P450-mediated etoposide metabolism.
Drug Metab. Dispos., Sep;32(9):993-1000 (2004)
1,4-Benzoquinone is a topoisomerase II poison.
Biochemistry., Jun;43(23):7563-74 (2004)
Plasma etoposide catechol increases in pediatric patients undergoing multiple-day chemotherapy with etoposide.
Clin. Cancer Res., May;10(9):2977-85 (2004)
Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing.
Oncogene., Nov;22(52):8448-59 (2003)
Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation.
Proc. Natl. Acad. Sci. U.S.A., Aug;98(17):9802-7 (2001)
Association of CYP3A4 genotype with treatment-related leukemia.
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Secondary leukemias induced by topoisomerase-targeted drugs.
Biochim. Biophys. Acta., Oct;1400(1-3):233-55 (1998)
MLL genomic breakpoint distribution within the breakpoint cluster region in de novo leukemia in children.
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Association of germline p53 mutation with MLL segmental jumping translocation in treatment-related leukemia.
Blood., Jun;91(12):4451-6 (1998)
t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes.
Proc. Natl. Acad. Sci. U.S.A., May;95(11):6413-8 (1998)
Panhandle polymerase chain reaction amplifies MLL genomic translocation breakpoint involving unknown partner gene.
Blood., Dec;90(12):4679-86 (1997)
Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias.
Proc. Natl. Acad. Sci. U.S.A., Oct;94(21):11583-8 (1997)
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p53 gene mutations in pediatric brain tumors.
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Identification of an altered immunoglobulin heavy-chain gene rearrangement in the central nervous system in B-precursor acute lymphoblastic leukemia.
Leukemia., Aug;7(8):1294-9 (1993)
Characterization of immunoglobulin and T-cell receptor gene patterns in B-cell precursor acute lymphoblastic leukemia of childhood.
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Characterization of the breakpoint of a t(14;14)(q11.2;q32) from the leukemic cells of a patient with T-cell acute lymphoblastic leukemia.
Cancer Genet. Cytogenet., Jan;44(1):47-54 (1990)
Massive acute hemolysis secondary to Clostridium perfringens sepsis in a recently transfused oncology patient with multiple alloantibodies.
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