Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL.
J. Lipid Res., Nov (2012)
High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE.
Clin Transl Sci., Oct;5(5):394-9 (2012)
Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci.
Am. J. Hum. Genet., Nov;91(5):823-38 (2012)
Results of genome-wide analyses on neurodevelopmental phenotypes at four-year follow-up following cardiac surgery in infancy.
PLoS ONE., 7(9):e45936 (2012)
Leveraging the electronic health record to implement genomic medicine.
Genet. Med., Sep (2012)
Beneficence, clinical urgency, and the return of individual research results to relatives.
Am J Bioeth., 12(10):9-10 (2012)
Dietary cholesterol increases paraoxonase 1 enzyme activity.
J. Lipid Res., Nov;53(11):2450-8 (2012)
Additional Common Polymorphisms in the PON Gene Cluster Predict PON1 Activity but Not Vascular Disease.
J Lipids., 2012:476316 (2012)
ColoSeq provides comprehensive lynch and polyposis syndrome mutational analysis using massively parallel sequencing.
J Mol Diagn., Jul;14(4):357-66 (2012)
Detectable clonal mosaicism from birth to old age and its relationship to cancer.
Nat. Genet., Jun;44(6):642-50 (2012)
Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits.
Mayo Clin. Proc., May;87(5):461-74 (2012)
Return of individual research results from genome-wide association studies: experience of the Electronic Medical Records and Genomics (eMERGE) Network.
Genet. Med., Apr;14(4):424-31 (2012)
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
Am. J. Hum. Genet., Mar;90(3):410-25 (2012)
Technical desiderata for the integration of genomic data into Electronic Health Records.
J Biomed Inform., Jun;45(3):419-22 (2012)
Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality.
Genet. Epidemiol., Dec;35(8):887-98 (2011)
Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study.
J Am Med Inform Assoc., 19(2):212-8 (2012 Mar-Apr)
Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network.
Hum. Genet., Apr;131(4):639-52 (2012)
Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies.
Am. J. Hum. Genet., Oct;89(4):529-42 (2011)
Follow-up of carriers of BRCA1 and BRCA2 variants of unknown significance: variant reclassification and surgical decisions.
Genet. Med., Dec;13(12):998-1005 (2011)
Linkage and association of phospholipid transfer protein activity to LASS4.
J. Lipid Res., Oct;52(10):1837-46 (2011)
Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate.
Am. J. Hum. Genet., Jul;89(1):131-8 (2011)
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Nat. Genet., May;43(5):436-41 (2011)
Genomics of the NF-ÎºB signaling pathway: hypothesized role in ovarian cancer.
Cancer Causes Control., May;22(5):785-801 (2011)
Comment on "Multidimensional results reporting to participants in genomic studies: getting it right".
Sci Transl Med., Feb;3(70):70le1 (2011)
The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies.
BMC Med Genomics., 4:13 (2011)
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.
Am. J. Hum. Genet., Jan;88(1):6-18 (2011)
Ethical and practical guidelines for reporting genetic research results to study participants: updated guidelines from a National Heart, Lung, and Blood Institute working group.
Circ Cardiovasc Genet., Dec;3(6):574-80 (2010)
Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk.
Stroke., Jan;42(1):2-9 (2011)
J. Maxwell Chamberlain Memorial Paper for congenital heart surgery. Deep hypothermic circulatory arrest does not impair neurodevelopmental outcome in school-age children after infant cardiac surgery.
Ann. Thorac. Surg., Dec;90(6):1985-94; discussion 1994-5 (2010)
Is cardiac diagnosis a predictor of neurodevelopmental outcome after cardiac surgery in infancy?
J. Thorac. Cardiovasc. Surg., Dec;140(6):1230-7 (2010)
Glad you asked: participants' opinions of re-consent for dbGap data submission.
J Empir Res Hum Res Ethics., Sep;5(3):9-16 (2010)
CLIA-tested genetic variants on commercial SNP arrays: potential for incidental findings in genome-wide association studies.
Genet. Med., Jun;12(6):355-63 (2010)
Genomic research and wide data sharing: views of prospective participants.
Genet. Med., Aug;12(8):486-95 (2010)
Linkage and association analyses identify a candidate region for apoB level on chromosome 4q32.3 in FCHL families.
Hum. Genet., Jun;127(6):705-19 (2010)
Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group.
Circulation., Mar;121(12):1447-54 (2010)
Human PON1, a biomarker of risk of disease and exposure.
Chem. Biol. Interact., Sep;187(1-3):355-61 (2010)
Paraoxonase 1 status as a risk factor for disease or exposure.
Adv. Exp. Med. Biol., 660:29-35 (2010)
Arterial remodeling in [corrected] subclinical carotid artery disease.
JACC Cardiovasc Imaging., Dec;2(12):1381-9 (2009)
Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study.
Ann. Hum. Genet., Jan;74(1):1-10 (2010)
Determination of paraoxonase 1 status without the use of toxic organophosphate substrates.
Circ Cardiovasc Genet., Dec;1(2):147-52 (2008)
Genetic and nongenetic sources of variation in phospholipid transfer protein activity.
J. Lipid Res., May;51(5):983-90 (2010)
Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
Lipids Health Dis., 8:52 (2009)
National Institutes of Health State-of-the-Science Conference Statement: Family History and Improving Health.
Ann. Intern. Med., Dec;151(12):872-7 (2009)
Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.
J. Atheroscler. Thromb., Aug;16(4):419-30 (2009)
National Institutes of Health State-of-the-Science Conference Statement: Family History and Improving Health: August 24-26, 2009.
NIH Consens State Sci Statements., Aug;26(1):1-19 (2009)
Perioperative stroke in infants undergoing open heart operations for congenital heart disease.
Ann. Thorac. Surg., Sep;88(3):823-9 (2009)
Apolipoprotein E genotype modifies the risk of behavior problems after infant cardiac surgery.
Pediatrics., Jul;124(1):241-50 (2009)
Predictors of impaired neurodevelopmental outcomes at one year of age after infant cardiac surgery.
Eur J Cardiothorac Surg., Jul;36(1):40-7 (2009)
Prediction of periventricular leukomalacia. Part II: Selection of hemodynamic features using computational intelligence.
Artif Intell Med., Jul;46(3):217-31 (2009)
Prediction of periventricular leukomalacia. Part I: Selection of hemodynamic features using logistic regression and decision tree algorithms.
Artif Intell Med., Jul;46(3):201-15 (2009)
Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.
J. Lipid Res., May;50(5):798-806 (2009)
Paraoxonase 1 (PON1) status and substrate hydrolysis.
Toxicol. Appl. Pharmacol., Feb;235(1):1-9 (2009)
Frequent detection of familial hypercholesterolemia mutations in familial combined hyperlipidemia.
J. Am. Coll. Cardiol., Nov;52(19):1554-6 (2008)
Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis.
Am. J. Respir. Crit. Care Med., Oct;178(7):710-20 (2008)
Comparison of tagging single-nucleotide polymorphism methods in association analyses.
BMC Proc., 1 Suppl 1:S6 (2007)
Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammation.
Arterioscler. Thromb. Vasc. Biol., Jul;28(7):1407-12 (2008)
Neurodevelopmental outcomes after staged palliation for hypoplastic left heart syndrome.
Pediatrics., Mar;121(3):476-83 (2008)
Genetic factors are important determinants of neurodevelopmental outcome after repair of tetralogy of Fallot.
J. Thorac. Cardiovasc. Surg., Jan;135(1):91-7 (2008)
A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk.
J. Lipid Res., Mar;49(3):588-96 (2008)
Heritability of longitudinal measures of body mass index and lipid and lipoprotein levels in aging twins.
Twin Res Hum Genet., Oct;10(5):703-11 (2007)
Patient characteristics are important determinants of neurodevelopmental outcome at one year of age after neonatal and infant cardiac surgery.
J. Thorac. Cardiovasc. Surg., May;133(5):1344-53, 1353.e1-3 (2007)
TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects.
Hum. Genet., Mar;121(1):65-75 (2007)
Inflammatory response after influenza vaccination in men with and without carotid artery disease.
Arterioscler. Thromb. Vasc. Biol., Dec;26(12):2738-44 (2006)
Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imaging.
Atherosclerosis., Oct;194(2):e34-42 (2007)
Neurodevelopmental outcome after early repair of a ventricular septal defect with or without aortic arch obstruction.
J. Thorac. Cardiovasc. Surg., Apr;131(4):792-8 (2006)
Reporting genetic results in research studies: summary and recommendations of an NHLBI working group.
Am. J. Med. Genet. A., May;140(10):1033-40 (2006)
TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular disease.
J. Lipid Res., May;47(5):1014-24 (2006)
Bias of allele-sharing linkage statistics in the presence of intermarker linkage disequilibrium.
BMC Genet., 6 Suppl 1:S82 (2005)
The role of parametric linkage methods in complex trait analyses using microsatellites.
BMC Genet., 6 Suppl 1:S48 (2005)
The relationship of postoperative electrographic seizures to neurodevelopmental outcome at 1 year of age after neonatal and infant cardiac surgery.
J. Thorac. Cardiovasc. Surg., Jan;131(1):181-9 (2006)
Assessment and implications of linkage disequilibrium in genome-wide single-nucleotide polymorphism and microsatellite panels.
Genet. Epidemiol., 29 Suppl 1:S72-6 (2005)
Effect of congenital heart disease on neurodevelopmental outcomes within multiple-gestation births.
J. Thorac. Cardiovasc. Surg., Dec;130(6):1511-6 (2005)
Increasing duration of deep hypothermic circulatory arrest is associated with an increased incidence of postoperative electroencephalographic seizures.
J. Thorac. Cardiovasc. Surg., Nov;130(5):1278-86 (2005)
Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants.
Neurotoxicology., Aug;26(4):651-9 (2005)
The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status.
J. Lipid Res., Sep;46(9):1888-95 (2005)
A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics.
Am. J. Hum. Genet., Aug;77(2):219-29 (2005)
Genome scan for quantitative trait loci influencing HDL levels: evidence for multilocus inheritance in familial combined hyperlipidemia.
Hum. Genet., Sep;117(5):494-505 (2005)
Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study.
Circulation., May;111(21):2768-75 (2005)
Ex vivo measures of LDL oxidative susceptibility predict carotid artery disease.
Atherosclerosis., Mar;179(1):147-53 (2005)
Low-density lipoprotein particle size loci in familial combined hyperlipidemia: evidence for multiple loci from a genome scan.
Arterioscler. Thromb. Vasc. Biol., Oct;24(10):1942-50 (2004)
Determination of paraoxonase 1 status and genotypes at specific polymorphic sites.
Curr Protoc Toxicol., May;Chapter 4:Unit4.12 (2004)
Periventricular leukomalacia is common after neonatal cardiac surgery.
J. Thorac. Cardiovasc. Surg., Mar;127(3):692-704 (2004)
Multiple genome-wide analyses of smoking behavior in the Framingham Heart Study.
BMC Genet., 4 Suppl 1:S102 (2003)
An examination of the genotyping error detection function of SIMWALK2.
BMC Genet., 4 Suppl 1:S40 (2003)
Identification of a prostate cancer susceptibility locus on chromosome 7q11-21 in Jewish families.
Proc. Natl. Acad. Sci. U.S.A., Feb;101(7):1939-44 (2004)
Apolipoprotein E genotype and neurodevelopmental sequelae of infant cardiac surgery.
J. Thorac. Cardiovasc. Surg., Dec;126(6):1736-45 (2003)
Summary report: Missing data and pedigree and genotyping errors.
Genet. Epidemiol., 25 Suppl 1:S36-42 (2003)
Genomic scan of 254 hereditary prostate cancer families.
Prostate., Dec;57(4):309-19 (2003)
Evidence of linkage of HDL level variation to APOC3 in two samples with different ascertainment.
Hum. Genet., Nov;113(6):522-33 (2003)
Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease.
Arterioscler. Thromb. Vasc. Biol., Aug;23(8):1465-71 (2003)
Oligogenic segregation analysis of hereditary prostate cancer pedigrees: evidence for multiple loci affecting age at onset.
Int. J. Cancer., Jul;105(5):630-5 (2003)
Novel paraoxonase (PON1) nonsense and missense mutations predicted by functional genomic assay of PON1 status.
Pharmacogenetics., May;13(5):291-5 (2003)
Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism.
Annu. Rev. Med., 54:371-92 (2003)
Vitamin C and E intake is associated with increased paraoxonase activity.
Arterioscler. Thromb. Vasc. Biol., Aug;22(8):1329-33 (2002)
Pharmacogenomic considerations of the paraoxonase polymorphisms.
Pharmacogenomics., May;3(3):341-8 (2002)
Genetic association studies: genes in search of diseases.
Neurology., Oct;57(7):1153-4 (2001)
Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression.
Am. J. Hum. Genet., Jun;68(6):1428-36 (2001)