Identification and characterization of a broadly cross-reactive HIV-1 human monoclonal antibody that binds to both gp120 and gp41.
PLoS ONE., 7(9):e44241 (2012)
Phage Display-directed Discovery of LEDGF/p75 Binding Cyclic Peptide Inhibitors of HIV Replication.
Mol. Ther., Nov;20(11):2064-75 (2012)
Isolation of monoclonal antibodies with predetermined conformational epitope specificity.
PLoS ONE., 7(6):e38943 (2012)
Dynamics of envelope evolution in clade C SHIV-infected pig-tailed macaques during disease progression analyzed by ultra-deep pyrosequencing.
PLoS ONE., 7(3):e32827 (2012)
No acquisition: a new ambition for HIV vaccine development?
Curr Opin Virol., Oct;1(4):246-53 (2011)
Efficiency of neutralizing antibodies targeting the CD4-binding site: influence of conformational masking by the V2 loop in R5-tropic clade C simian-human immunodeficiency virus.
J. Virol., Dec;85(23):12811-4 (2011)
High-level, lasting antiviral immunity induced by a bimodal AIDS vaccine and boosted by live-virus exposure: prevention of viremia.
AIDS., Jan;26(2):149-55 (2012)
Molecularly cloned SHIV-CN97001: a replication-competent, R5 simian/human immunodeficiency virus containing env of a primary Chinese HIV-1 clade C isolate.
J. Med. Primatol., Dec;40(6):427-36 (2011)
Schistosoma mansoni enhances host susceptibility to mucosal but not intravenous challenge by R5 Clade C SHIV.
PLoS Negl Trop Dis., Aug;5(8):e1270 (2011)
Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection.
PLoS ONE., 6(7):e22010 (2011)
Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges.
Vaccine., Aug;29(34):5611-22 (2011)
An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV.
PLoS ONE., 6(3):e18207 (2011)
R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes.
PLoS ONE., 6(4):e18465 (2011)
Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV.
J Immune Based Ther Vaccines., 9:2 (2011)
A live attenuated Listeria monocytogenes vaccine vector expressing SIV Gag is safe and immunogenic in macaques and can be administered repeatedly.
Vaccine., Jan;29(3):476-86 (2011)
Development of a tier 1 R5 clade C simian-human immunodeficiency virus as a tool to test neutralizing antibody-based immunoprophylaxis.
J. Med. Primatol., Apr;40(2):120-8 (2011)
R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models.
PLoS ONE., 5(7):e11689 (2010)
Bimodal AIDS vaccine approach: induction of cellular as well as humoral immunity can protect from systemic infection.
Vaccine., May;28 Suppl 2:B25-31 (2010)
AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4.
J. Med. Primatol., Oct;39(5):356-60 (2010)
Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes.
J. Infect. Dis., Apr;201(8):1155-63 (2010)
A comparative study of HIV-1 clade C env evolution in a Zambian infant with an infected rhesus macaque during disease progression.
AIDS., Sep;23(14):1817-28 (2009)
Pathogenic infection of Macaca nemestrina with a CCR5-tropic subtype-C simian-human immunodeficiency virus.
Retrovirology., 6:65 (2009)
CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids.
J. Exp. Med., Jun;206(6):1409-22 (2009)
Passive immunization with human neutralizing monoclonal antibodies against HIV-1 in macaque models: experimental approaches.
Methods Mol. Biol., 525:559-66, xiv (2009)
Overlapping synthetic peptides encoding TPD52 as breast cancer vaccine in mice: prolonged survival.
Vaccine., Mar;27(12):1825-33 (2009)
Generation of recombinant vaccinia viruses via green fluorescent protein selection.
DNA Cell Biol., Mar;28(3):103-8 (2009)
Inducing cross-clade neutralizing antibodies against HIV-1 by immunofocusing.
PLoS ONE., 3(12):e3937 (2008)
Neutralization-sensitive R5-tropic simian-human immunodeficiency virus SHIV-2873Nip, which carries env isolated from an infant with a recent HIV clade C infection.
J. Virol., Feb;83(3):1422-32 (2009)
SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeys.
Retrovirology., 5:94 (2008)
Acute Schistosoma mansoni infection increases susceptibility to systemic SHIV clade C infection in rhesus macaques after mucosal virus exposure.
PLoS Negl Trop Dis., 2(7):e265 (2008)
Cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody that recognizes a novel conformational epitope on gp41 and lacks reactivity against self-antigens.
J. Virol., Jul;82(14):6869-79 (2008)
Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccination.
Virology., Jun;375(2):315-20 (2008)
Passive immunization as tool to identify protective HIV-1 Env epitopes.
Curr. HIV Res., Nov;5(6):642-55 (2007)
Live attenuated Listeria monocytogenes expressing HIV Gag: immunogenicity in rhesus monkeys.
Vaccine., Oct;25(42):7470-9 (2007)
Efficacy of a multigenic protein vaccine containing multimeric HIV gp160 against heterologous SHIV clade C challenges.
AIDS., Sep;21(14):1841-8 (2007)
Dendritic cell-based vaccine strategy against human immunodeficiency virus clade C: skewing the immune response toward a helper T cell type 2 profile.
Viral Immunol., 20(1):160-9 (2007)
Coinfection with Schistosoma mansoni reactivates viremia in rhesus macaques with chronic simian-human immunodeficiency virus clade C infection.
Infect. Immun., Apr;75(4):1751-6 (2007)
AIDS vaccine development and challenge viruses: getting real.
AIDS., Nov;20(17):2135-40 (2006)
Characterization of HIV-1 subtype C envelope glycoproteins from perinatally infected children with different courses of disease.
Retrovirology., 3:73 (2006)
Time dependence of protective post-exposure prophylaxis with human monoclonal antibodies against pathogenic SHIV challenge in newborn macaques.
Virology., Feb;358(1):69-78 (2007)
Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques.
AIDS Res. Hum. Retroviruses., Jun;22(6):516-28 (2006)
Overlapping synthetic peptides as vaccines.
Vaccine., Sep;24(37-39):6356-65 (2006)
DNA prime/protein boost immunization against HIV clade C: safety and immunogenicity in mice.
Vaccine., Mar;24(13):2324-32 (2006)
Schistosoma mansoni infection promotes SHIV clade C replication in rhesus macaques.
AIDS., Nov;19(16):1793-7 (2005)
Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques.
J. Virol., Jul;79(13):8131-41 (2005)
Molecular cloning and in vitro evaluation of an infectious simian-human immunodeficiency virus containing env of a primary Chinese HIV-1 subtype C isolate.
J. Med. Primatol., Apr;34(2):101-7 (2005)
Dichotomy in cross-clade reactivity and neutralization by HIV-1 sera: Implications for active and passive immunotherapy.
J. Med. Virol., Jun;76(2):146-52 (2005)
Phosphorylation of HIV Nef by cAMP-dependent protein kinase.
Virology., Jan;331(2):367-74 (2005)
Older rhesus macaque infants are more susceptible to oral infection with simian-human immunodeficiency virus 89.6P than neonates.
J. Virol., Jan;79(2):1333-6 (2005)
Long-term productive human immunodeficiency virus infection of CD1a-sorted myeloid dendritic cells.
J. Virol., Jan;79(1):602-8 (2005)
Infectious molecular clone of a recently transmitted pediatric human immunodeficiency virus clade C isolate from Africa: evidence of intraclade recombination.
J. Virol., Dec;78(24):14066-9 (2004)
Synthesis and assembly of SIVmac Gag p27 capsid protein cholera toxin B subunit fusion protein in transgenic potato.
Mol. Biotechnol., Sep;28(1):33-40 (2004)
Complete protection of neonatal rhesus macaques against oral exposure to pathogenic simian-human immunodeficiency virus by human anti-HIV monoclonal antibodies.
J. Infect. Dis., Jun;189(12):2167-73 (2004)
Live attenuated HIV vaccines: pitfalls and prospects.
Curr. Opin. Infect. Dis., Feb;17(1):17-26 (2004)
Potent cross-group neutralization of primary human immunodeficiency virus isolates with monoclonal antibodies--implications for acquired immunodeficiency syndrome vaccine.
J. Infect. Dis., Jan;189(1):71-4 (2004)